Genetic variants in HFE are associated with non-alcoholic fatty liver disease in lean individuals.
Sun Z, Pan X, Tian A et al.
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Abstract
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Background & aims: Around 20% of patients with non-alcoholic fatty liver disease (NAFLD) are lean. Increasing evidence suggests that lean NAFLD is a unique subtype of the disease. We aimed to explore the metabolic profile, genetic basis, causal risk factors, and clinical sequelae underlying lean NAFLD.
6,623 European ancestry cases, 26,318 European ancestry controls
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