Beyond apples and pears: sex-specific genetics of body fat percentage.
Roshandel D, Lu T, Paterson AD et al.
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Abstract
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Introduction: Biological sex influences both overall adiposity and fat distribution. Further, testosterone and sex hormone binding globulin (SHBG) influence adiposity and metabolic function, with differential effects of testosterone in men and women. Here, we aimed to perform sex-stratified genome-wide association studies (GWAS) of body fat percentage (BFPAdj) (adjusting for testosterone and sex hormone binding globulin (SHBG)) to increase statistical power.
154,337 British ancestry females
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