Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1.
Clifford R, Munro D, Dochtermann D et al.
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Abstract
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Purpose: Chronic age-related imbalance is a common cause of falls and subsequent death in the elderly and can arise from dysfunction of the vestibular system, an elegant neuroanatomical group of pathways that mediates human perception of acceleration, gravity, and angular head motion. Studies indicate that 27-46% of the risk of age-related chronic imbalance is genetic; nevertheless, the underlying genes remain unknown.
10,135 African American cases, 69,253 African American controls, 36,573 European ancestry cases, 267,170 European ancestry controls, 3,631 Latin ancestry cases, 30,477 Latin ancestry controls
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