Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis.
Liu R, Shang X, Fu Y et al.
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Abstract
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In recent years, mounting evidence has indicated a co-morbid relationship between hypothyroidism and rheumatoid arthritis (RA), however, the shared genetic factors underlying this association remain unclear. This study aims to investigate the common genetic architecture between hypothyroidism and RA.
22,350 European ancestry rheumatoid arthritis cases, 51,194 European ancestry hypothyroidism cases, 518,206 European ancestry controls
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