Genome-wide association study and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer.
Laskar RS, Qu C, Huyghe JR et al.
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Abstract
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The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. CRC has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization (MR) analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC.
6,176 European ancestry cases, 65,829 European ancestry controls
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