Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis.
Pott J, Kheirkhah A, Gadin JR et al.
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Abstract
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in women throughout their life. Statin treatment affects PCSK9 levels also showing evidence of sex-differential effects. It remains unclear whether these differences can be explained by genetics.
7,183 European ancestry females
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