Germline genetic regulation of the colorectal tumor immune microenvironment.
Schmit SL, Tsai YY, Bonner JD et al.
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Abstract
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Objective: To evaluate the contribution of germline genetics to regulating the briskness and diversity of T cell responses in CRC, we conducted a genome-wide association study to examine the associations between germline genetic variation and quantitative measures of T cell landscapes in 2,876 colorectal tumors from participants in the Molecular Epidemiology of Colorectal Cancer Study (MECC).
2,395 individuals
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