The genetic architecture of cervical length is shared with spontaneous preterm birth risk.
Wolf HM, Webb BT, Strauss JF et al.
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Abstract
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Sonographic cervical length is a powerful predictor of maternal risk for spontaneous preterm birth (sPTB). Twin and family studies have established a maternal genetic heritability for sPTB ranging from 13 to 20%, however, there is no corresponding estimate for the heritability of mid-trimester cervical length, or an understanding of how genetic factors contribute to cervical changes across pregnancy.
4,423 African American females
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