Multi-ancestry meta-analysis identifies genetic modifiers of age-at-onset of Alzheimer's disease at known and novel loci.
Blue EE, Broome J, Xue D et al.
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Abstract
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Introduction: Much of Alzheimer's disease (AD) risk is explained by age, apolipoprotein E (APOE) genotype, and sex. We sought to identify genetic modifiers of age at onset (AAO) of AD while probing the influence of sex and APOE among those with diverse ancestry.
27,993 European ancestry individuals, 6,949 Black individuals, 6,530 Hispanic individuals, 55 individuals
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