Sex-specific genetic effects on susceptibility to idiopathic pulmonary fibrosis.
Leavy OC, Goemans AF, Hernandez-Beeftink T et al.
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Abstract
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Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition that is more prevalent in males than females. The reasons for this are not fully understood; differing environmental exposures due to historically sex-biased occupations and diagnostic bias are possible explanations. To date, over 20 independent genetic association signals have been reported for IPF susceptibility, but these have been discovered when combining males and females. The objectives of the present study were to assess whether there is a need to consider sex-specific effects when evaluating genetic risk in clinical prediction models for IPF and to test for sex-specific associations with IPF susceptibility.
4,561 European ancestry cases, 22,888 European ancestry controls
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