Cross-ancestry discovery of genetic risk variants for lean metabolic dysfunction-associated steatotic liver disease.
Hsu SW, Lin MR, Chou WH et al.
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Abstract
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The presence of metabolic dysfunction-associated steatotic liver disease (MASLD) in lean patients challenges the traditional association between fatty liver and obesity. While genome-wide association studies (GWAS) have identified key genetic variants linked to hepatic steatosis, most have focused on Western obese populations and were based on the former non-alcoholic fatty liver disease (NAFLD) criteria. Genetic studies targeting lean MASLD, particularly among the Taiwan Han Chinese population, remain limited. This study addresses this knowledge gap by investigating the genetic architecture of lean MASLD in a Taiwan Han Chinese cohort.
1,720 Taiwan Han Chinese ancestry cases, 5,331 Taiwan Han Chinese ancestry controls
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