Active: Abdominal aortic aneurysm Clear all

GWAS 2023-10-16

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.

Roychowdhury T, Klarin D et al.

Nat Genet

Abdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we...

Abdominal aortic aneurysm

1125328

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-02

Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.

Portilla-Fernandez E, Klarin D et al.

Hum Mol Genet

Progressive dilation of the infrarenal aortic diameter is a consequence of the ageing process and is...

Abdominal aortic diameter

Replicated

13542

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-01

Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort.

Ashvetiya T, Fan SX et al.

PLoS One

Thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) are known to have a strong geneti...

Abdominal aortic aneurysm

28623

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-28

Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program.

Klarin D, Verma SS et al.

Circulation

Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its gene...

Abdominal aortic aneurysm

Replicated

290118

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-01

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

Klarin D, Damrauer SM et al.

Nat Genet

The Million Veteran Program (MVP) was established in 2011 as a national research initiative to deter...

HDL cholesterol

Replicated

617303

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-29

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Jones GT, Tromp G et al.

Circ Res

Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental ...

Abdominal aortic aneurysm

Replicated

117970

Participants

N/A

Studies

Details PubMed

GWAS 2016-07-14

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

van 't Hof FN, Ruigrok YM et al.

J Am Heart Assoc

Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs...

Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy)

12601

Participants

N/A

Studies

Details PubMed

GWAS 2013-09-17

A variant in LDLR is associated with abdominal aortic aneurysm.

Bradley DT, Hughes AE et al.

Circ Cardiovasc Genet

Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrat...

Abdominal aortic aneurysm

Replicated

43205

Participants

N/A

Studies

Details PubMed

GWAS 2011-11-04

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.

Bown MJ, Jones GT et al.

Am J Hum Genet

Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant h...

Abdominal aortic aneurysm

Replicated

51048

Participants

N/A

Studies

Details PubMed

GWAS 2010-07-11

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Gretarsdottir S, Baas AF et al.

Nat Genet

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (A...

Abdominal aortic aneurysm

Replicated

42513

Participants

N/A

Studies

Details PubMed

GWAS 2009-06-06

Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association.

Elmore JR, Obmann MA et al.

J Vasc Surg

Objective: The goal of this project was to identify genetic variants associated with abdominal aorti...

Abdominal aortic aneurysm

Replicated

2096

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.

Roychowdhury T, Klarin D et al.

Nat Genet

Abdominal aortic aneurysm

2023-10-16

Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.

Portilla-Fernandez E, Klarin D et al.

Hum Mol Genet

Abdominal aortic diameter

2022-03-02

Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort.

Ashvetiya T, Fan SX et al.

PLoS One

Abdominal aortic aneurysm

2021-09-01

Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program.

Klarin D, Verma SS et al.

Circulation

Abdominal aortic aneurysm

2020-09-28

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

Klarin D, Damrauer SM et al.

Nat Genet

HDL cholesterol

2018-10-01

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Jones GT, Tromp G et al.

Circ Res

Abdominal aortic aneurysm

2016-11-29

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

van 't Hof FN, Ruigrok YM et al.

J Am Heart Assoc

Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy)

2016-07-14

A variant in LDLR is associated with abdominal aortic aneurysm.

Bradley DT, Hughes AE et al.

Circ Cardiovasc Genet

Abdominal aortic aneurysm

2013-09-17

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.

Bown MJ, Jones GT et al.

Am J Hum Genet

Abdominal aortic aneurysm

2011-11-04

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Gretarsdottir S, Baas AF et al.

Nat Genet

Abdominal aortic aneurysm

2010-07-11

Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association.

Elmore JR, Obmann MA et al.

J Vasc Surg

Abdominal aortic aneurysm

2009-06-06