Active: Age at natural menopause Clear all

GWAS 2024-05-03

A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma.

Wu X, Xiao C et al.

PLoS Genet

Age at first sexual intercourse (AFS) and lifetime number of sexual partners (NSP) may influence the...

Age at first sexual intercourse or uterine leiomyoma (pleiotropy)

517526

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-01

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

There is currently little evidence that the genetic basis of human phenotype varies significantly ac...

Age at natural menopause

Replicated

243506

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-01

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.

D'Urso S, Arumugam P et al.

BMC Med

Observational epidemiological studies suggest a link between several factors related to ovulation an...

Age at last live birth

203153

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-04

Genetic insights into biological mechanisms governing human ovarian ageing.

Ruth KS, Day FR et al.

Nature

Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but ins...

Age at natural menopause

Replicated

574468

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-29

Joint genome-wide association analyses identified 49 novel loci for age at natural menopause.

Zhang L, Wei XT et al.

J Clin Endocrinol Metab

Age at natural menopause (ANM) is an important index for women's health. Either early or late ANM is...

Age at menopause

181219

Participants

N/A

Studies

Details PubMed

GWAS 2018-07-25

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.

Fernández-Rhodes L, Malinowski JR et al.

PLoS One

Current knowledge of the genetic architecture of key reproductive events across the female life cour...

Age at menopause

17730

Participants

N/A

Studies

Details PubMed

GWAS 2015-11-01

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Day FR, Ruth KS et al.

Nat Genet

Menopause timing has a substantial impact on infertility and risk of disease, including breast cance...

Menopause (age at onset)

Replicated

69626

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-16

Shared genetic factors for age at natural menopause in Iranian and European women.

Rahmani M, Earp MA et al.

Hum Reprod

Study question: Do differences in heritable genetic factors explain some of the difference in age at...

Menopause (age at onset)

Replicated

39893

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-09

A genome-wide association study of early menopause and the combined impact of identified variants.

Perry JR, Corre T et al.

Hum Mol Genet

Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan cons...

Menopause (age at onset)

Replicated

25431

Participants

N/A

Studies

Details PubMed

GWAS 2012-01-22

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Stolk L, Perry JR et al.

Nat Genet

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wid...

Menopause (age at onset)

Replicated

53403

Participants

N/A

Studies

Details PubMed

GWAS 2009-05-17

Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.

He C, Kraft P et al.

Nat Genet

Age at menarche and age at natural menopause are associated with causes of substantial morbidity and...

Menarche and menopause (age at onset)

17438

Participants

N/A

Studies

Details PubMed

GWAS 2009-05-15

Loci at chromosomes 13, 19 and 20 influence age at natural menopause.

Stolk L, Zhai G et al.

Nat Genet

We conducted a genome-wide association study for age at natural menopause in 2,979 European women an...

Menopause (age at onset)

Replicated

5539

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma.

Wu X, Xiao C et al.

PLoS Genet

Age at first sexual intercourse or uterine leiomyoma (pleiotropy)

2024-05-03

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

Age at natural menopause

2023-08-01

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.

D'Urso S, Arumugam P et al.

BMC Med

Age at last live birth

2022-11-01

Genetic insights into biological mechanisms governing human ovarian ageing.

Ruth KS, Day FR et al.

Nature

Age at natural menopause

2021-08-04

Joint genome-wide association analyses identified 49 novel loci for age at natural menopause.

Zhang L, Wei XT et al.

J Clin Endocrinol Metab

Age at menopause

2021-05-29

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.

Fernández-Rhodes L, Malinowski JR et al.

PLoS One

Age at menopause

2018-07-25

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Day FR, Ruth KS et al.

Nat Genet

Menopause (age at onset)

2015-11-01

Shared genetic factors for age at natural menopause in Iranian and European women.

Rahmani M, Earp MA et al.

Hum Reprod

Menopause (age at onset)

2013-04-16

A genome-wide association study of early menopause and the combined impact of identified variants.

Perry JR, Corre T et al.

Hum Mol Genet

Menopause (age at onset)

2013-01-09

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Stolk L, Perry JR et al.

Nat Genet

Menopause (age at onset)

2012-01-22

Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.

He C, Kraft P et al.

Nat Genet

Menarche and menopause (age at onset)

2009-05-17

Loci at chromosomes 13, 19 and 20 influence age at natural menopause.

Stolk L, Zhai G et al.

Nat Genet

Menopause (age at onset)

2009-05-15