Active: Alzheimer's disease (late onset) Clear all

GWAS 2019-02-28

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Kunkle BW, Grenier-Boley B et al.

Nat Genet

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by ...

Alzheimer's disease (late onset)

Replicated

94437

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-07

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

Jansen IE, Savage JE et al.

Nat Genet

Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 disease-asso...

Alzheimer's disease (late onset)

79145

Participants

N/A

Studies

Details PubMed

GWAS 2017-09-01

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Sims R, van der Lee SJ et al.

Nat Genet

We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control...

Alzheimer's disease (late onset)

Replicated

85133

Participants

N/A

Studies

Details PubMed

GWAS 2015-06-18

F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.

Tosto G, Fu H et al.

Ann Clin Transl Neurol

Objective: In the context of late-onset Alzheimer's disease (LOAD) over 20 genes have been identifie...

Alzheimer's disease (late onset)

Replicated

5300

Participants

N/A

Studies

Details PubMed

GWAS 2015-06-05

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.

Hirano A, Ohara T et al.

Psychiatr Genet

Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's di...

Alzheimer's disease (late onset)

Replicated

17031

Participants

N/A

Studies

Details PubMed

GWAS 2013-10-27

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Lambert JC, Ibrahim-Verbaas CA et al.

Nat Genet

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous stu...

Alzheimer's disease (late onset)

Replicated

75018

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-10

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.

Reitz C, Jun G et al.

JAMA

Importance: Genetic variants associated with susceptibility to late-onset Alzheimer disease are know...

Alzheimer's disease (late onset)

5896

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-02

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.

Miyashita A, Koike A et al.

PLoS One

To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage ge...

Alzheimer's disease (late onset)

Replicated

27844

Participants

N/A

Studies

Details PubMed

GWAS 2012-09-01

Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.

Cummings AC, Jiang L et al.

Ann Hum Genet

To identify novel late-onset Alzheimer disease (LOAD) risk genes, we have analysed Amish populations...

Alzheimer's disease (late onset)

798

Participants

N/A

Studies

Details PubMed

GWAS 2011-04-03

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Naj AC, Jun G et al.

Nat Genet

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-o...

Alzheimer's disease (late onset)

Replicated

54429

Participants

N/A

Studies

Details PubMed

GWAS 2011-02-24

Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.

Hu X, Pickering E et al.

PLoS One

Recent GWAS studies focused on uncovering novel genetic loci related to AD have revealed association...

Alzheimer's disease (late onset)

Replicated

5097

Participants

N/A

Studies

Details PubMed

GWAS 2011-02-17

Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

Wijsman EM, Pankratz ND et al.

PLoS Genet

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The Nation...

Alzheimer's disease (late onset)

Replicated

5029

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Kunkle BW, Grenier-Boley B et al.

Nat Genet

Alzheimer's disease (late onset)

2019-02-28

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

Jansen IE, Savage JE et al.

Nat Genet

Alzheimer's disease (late onset)

2019-01-07

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Sims R, van der Lee SJ et al.

Nat Genet

Alzheimer's disease (late onset)

2017-09-01

F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.

Tosto G, Fu H et al.

Ann Clin Transl Neurol

Alzheimer's disease (late onset)

2015-06-18

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.

Hirano A, Ohara T et al.

Psychiatr Genet

Alzheimer's disease (late onset)

2015-06-05

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Lambert JC, Ibrahim-Verbaas CA et al.

Nat Genet

Alzheimer's disease (late onset)

2013-10-27

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.

Reitz C, Jun G et al.

JAMA

Alzheimer's disease (late onset)

2013-04-10

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.

Miyashita A, Koike A et al.

PLoS One

Alzheimer's disease (late onset)

2013-04-02

Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.

Cummings AC, Jiang L et al.

Ann Hum Genet

Alzheimer's disease (late onset)

2012-09-01

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Naj AC, Jun G et al.

Nat Genet

Alzheimer's disease (late onset)

2011-04-03

Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.

Hu X, Pickering E et al.

PLoS One

Alzheimer's disease (late onset)

2011-02-24

Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

Wijsman EM, Pankratz ND et al.

PLoS Genet

Alzheimer's disease (late onset)

2011-02-17