Active: Arthritis Clear all

GWAS 2025-04-11

The genetic architecture of and evolutionary constraints on the human pelvic form.

Xu L, Kun E et al.

Science

Human pelvic evolution following the human-chimpanzee divergence is thought to result in an obstetri...

Acetabular diameter

31115

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-09

Translational genomics of osteoarthritis in 1,962,069 individuals.

Hatzikotoulas K, Southam L et al.

Nature

Osteoarthritis is the third most rapidly growing health condition associated with disability, after ...

Osteoarthritis

1962069

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-22

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.

Faber BG, Frysz M et al.

Hum Mol Genet

Objectives: Hip shape is thought to be an important causal risk factor for hip osteoarthritis and fr...

Hip shape mode 1

43485

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-17

Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis.

Liu R, Shang X et al.

Mol Immunol

In recent years, mounting evidence has indicated a co-morbid relationship between hypothyroidism and...

Hypothyroidism or rheumatoid arthritis (pleiotropy)

591750

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-05

Revealing Novel Genomic Insights and Therapeutic Targets for Juvenile Idiopathic Arthritis through Omics.

Fan J, Li X et al.

Rheumatology (Oxford)

The genetic architecture of JIA remains only partially comprehended. There is a clear imperative for...

Juvenile idiopathic arthritis

22996

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-10

Genome-Wide Assessment of Shared Genetic Architecture Between Rheumatoid Arthritis and Cardiovascular Diseases.

Guo Y, Chung W et al.

J Am Heart Assoc

Patients with rheumatoid arthritis (RA) have a 2- to 10-fold increased risk of cardiovascular diseas...

Hypertension

459138

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-11

Mexican Biobank advances population and medical genomics of diverse ancestries.

Sohail M, Palma-Martínez MJ et al.

Nature

Latin America continues to be severely underrepresented in genomics research, and fine-scale genetic...

Arthritis

5721

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-24

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

Zhang C, Shestopaloff K et al.

Am J Hum Genet

Response to the anti-IL17 monoclonal antibody secukinumab is heterogeneous, and not all participants...

Erythrocyte sedimentation rate x secukinumab treatment interaction in ankylosing spondylitis

754

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-22

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.

Faber BG, Frysz M et al.

EBioMedicine

Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to c...

Hip minimal joint space width

50745

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-10

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH, Stacey D et al.

Nat Immunol

Circulating proteins have important functions in inflammation and a broad range of diseases. To iden...

Eukaryotic translation initiation factor 4E-binding protein 1 levels

Replicated

16321

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-21

The genetic architecture and evolution of the human skeletal form.

Kun E, Javan EM et al.

Science

The human skeletal form underlies bipedalism, but the genetic basis of skeletal proportions (SPs) is...

Forearm length to body height ratio

31221

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-19

Life is pain: Fibromyalgia as a nexus of multiple liability distributions.

Moscati A, Faucon AB et al.

Am J Med Genet B Neuropsychiatr Genet

Fibromyalgia is a complex disease of unclear etiology that is complicated by difficulties in diagnos...

Fibromyalgia

16024

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

The genetic architecture of and evolutionary constraints on the human pelvic form.

Xu L, Kun E et al.

Science

Acetabular diameter

2025-04-11

Translational genomics of osteoarthritis in 1,962,069 individuals.

Hatzikotoulas K, Southam L et al.

Nature

Osteoarthritis

2025-04-09

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.

Faber BG, Frysz M et al.

Hum Mol Genet

Hip shape mode 1

2024-11-22

Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis.

Liu R, Shang X et al.

Mol Immunol

Hypothyroidism or rheumatoid arthritis (pleiotropy)

2024-02-17

Revealing Novel Genomic Insights and Therapeutic Targets for Juvenile Idiopathic Arthritis through Omics.

Fan J, Li X et al.

Rheumatology (Oxford)

Juvenile idiopathic arthritis

2024-02-05

Genome-Wide Assessment of Shared Genetic Architecture Between Rheumatoid Arthritis and Cardiovascular Diseases.

Guo Y, Chung W et al.

J Am Heart Assoc

Hypertension

2023-11-10

Mexican Biobank advances population and medical genomics of diverse ancestries.

Sohail M, Palma-Martínez MJ et al.

Nature

Arthritis

2023-10-11

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

Zhang C, Shestopaloff K et al.

Am J Hum Genet

Erythrocyte sedimentation rate x secukinumab treatment interaction in ankylosing spondylitis

2023-08-24

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.

Faber BG, Frysz M et al.

EBioMedicine

Hip minimal joint space width

2023-08-22

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH, Stacey D et al.

Nat Immunol

Eukaryotic translation initiation factor 4E-binding protein 1 levels

2023-08-10

The genetic architecture and evolution of the human skeletal form.

Kun E, Javan EM et al.

Science

Forearm length to body height ratio

2023-07-21

Life is pain: Fibromyalgia as a nexus of multiple liability distributions.

Moscati A, Faucon AB et al.

Am J Med Genet B Neuropsychiatr Genet

Fibromyalgia

2023-06-19