Active: Breast cancer Clear all

GWAS 2025-07-01

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers.

Wang S, Liu H et al.

Brief Bioinform

Fat distribution patterns are increasingly linked to obesity-related cancers; however, their shared ...

Leg fat ratio or ovarian cancer (pleiotropy)

127582

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-14

Genome-wide association study identifies common variants associated with breast cancer in South African Black women.

Hayat M, Chen WC et al.

Nat Commun

Genome-wide association studies (GWAS) have characterized the contribution of common variants to bre...

Breast cancer

3586

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-03

Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions.

Jia G, Chen Z et al.

Nat Genet

Genome-wide association studies have identified approximately 200 genetic risk loci for breast cance...

Breast cancer

127435

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-04

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants that Confer Risk for Breast Cancer.

Sun X, Verma SP et al.

Cancer Res

Breast cancer includes several subtypes with distinct characteristic biological, pathologic, and cli...

Breast cancer subtype (luminal B-like vs luminal A-like)

73129

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-28

Association of ESR1 germline variants with TP53 somatic variants in breast tumors in a genome-wide study.

Tjader NP, Beer AJ et al.

Cancer Res Commun

In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype and ancestry...

Breast cancer x TP53 loss of function mutation interaction

Replicated

3786

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-13

Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.

Jia G, Ping J et al.

Nat Genet

We performed genome-wide association studies of breast cancer including 18,034 cases and 22,104 cont...

Breast cancer

40138

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-06

Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.

Abar L, Zuber V et al.

NAR Genom Bioinform

Variations in serum amino acid levels are linked to a multitude of complex disorders. We report the ...

Alanine levels

117944

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-27

New role of fat-free mass in cancer risk linked with genetic predisposition.

Harris BHL, Di Giovannantonio M et al.

Sci Rep

Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-fr...

Postmenopausal breast cancer

175905

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-19

A Genome-Wide Association Study of Endoxifen Serum Concentrations and Adjuvant Tamoxifen Efficacy in Early-Stage Breast Cancer Patients.

Sanchez-Spitman AB, Böhringer S et al.

Clin Pharmacol Ther

Tamoxifen is part of the standard of care of endocrine therapy for adjuvant treatment of breast canc...

Endoxifen concentration in tamoxifen-treated breast cancer

608

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-23

A genome-wide association study of contralateral breast cancer in the Women's Environmental Cancer and Radiation Epidemiology Study.

Sun X, Reiner AS et al.

Breast Cancer Res

Contralateral breast cancer (CBC) is the most common second primary cancer diagnosed in breast cance...

Contralateral breast cancer vs unilateral breast cancer

2829

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-17

Association of Genetic Markers with the Risk of Early-Onset Breast Cancer in Kazakh Women.

Skvortsova L, Abdikerim S et al.

Genes (Basel)

Breast cancer is a global health problem. It is an age-dependent disease, but cases of early-onset b...

Breast cancer (early onset)

307

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-10

Polygenic risk score model for renal cell carcinoma in the Korean population and relationship with lifestyle-associated factors.

Hong JY, Han JH et al.

BMC Genomics

The polygenic risk score (PRS) is used to predict the risk of developing common complex diseases or ...

Renal cell carcinoma

4423

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers.

Wang S, Liu H et al.

Brief Bioinform

Leg fat ratio or ovarian cancer (pleiotropy)

2025-07-01

Genome-wide association study identifies common variants associated with breast cancer in South African Black women.

Hayat M, Chen WC et al.

Nat Commun

Breast cancer

2025-04-14

Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions.

Jia G, Chen Z et al.

Nat Genet

Breast cancer

2025-01-03

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants that Confer Risk for Breast Cancer.

Sun X, Verma SP et al.

Cancer Res

Breast cancer subtype (luminal B-like vs luminal A-like)

2024-06-04

Association of ESR1 germline variants with TP53 somatic variants in breast tumors in a genome-wide study.

Tjader NP, Beer AJ et al.

Cancer Res Commun

Breast cancer x TP53 loss of function mutation interaction

2024-05-28

Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.

Jia G, Ping J et al.

Nat Genet

Breast cancer

2024-05-13

Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.

Abar L, Zuber V et al.

NAR Genom Bioinform

Alanine levels

2024-05-06

New role of fat-free mass in cancer risk linked with genetic predisposition.

Harris BHL, Di Giovannantonio M et al.

Sci Rep

Postmenopausal breast cancer

2024-03-27

A Genome-Wide Association Study of Endoxifen Serum Concentrations and Adjuvant Tamoxifen Efficacy in Early-Stage Breast Cancer Patients.

Sanchez-Spitman AB, Böhringer S et al.

Clin Pharmacol Ther

Endoxifen concentration in tamoxifen-treated breast cancer

2024-03-19

A genome-wide association study of contralateral breast cancer in the Women's Environmental Cancer and Radiation Epidemiology Study.

Sun X, Reiner AS et al.

Breast Cancer Res

Contralateral breast cancer vs unilateral breast cancer

2024-01-23

Association of Genetic Markers with the Risk of Early-Onset Breast Cancer in Kazakh Women.

Skvortsova L, Abdikerim S et al.

Genes (Basel)

Breast cancer (early onset)

2024-01-17

Polygenic risk score model for renal cell carcinoma in the Korean population and relationship with lifestyle-associated factors.

Hong JY, Han JH et al.

BMC Genomics

Renal cell carcinoma

2024-01-10