Active: Central corneal thickness Clear all

GWAS 2020-06-11

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.

Choquet H, Melles RB et al.

Commun Biol

Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense heritabi...

Central corneal thickness

44039

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-27

Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.

Bonnemaijer PWM, Leeuwen EMV et al.

Commun Biol

A new avenue of mining published genome-wide association studies includes the joint analysis of rela...

Optic cup area

Replicated

24493

Participants

N/A

Studies

Details PubMed

GWAS 2019-03-20

Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.

Ivarsdottir EV, Benonisdottir S et al.

Nat Commun

The corneal endothelium is vital for transparency and proper hydration of the cornea. Here, we condu...

Corneal hysteresis

Replicated

6125

Participants

N/A

Studies

Details PubMed

GWAS 2018-05-14

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Iglesias AI, Mishra A et al.

Nat Commun

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases suc...

Central corneal thickness

25910

Participants

N/A

Studies

Details PubMed

GWAS 2018-05-01

Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.

Fan BJ, Chen X et al.

Invest Ophthalmol Vis Sci

Purpose: To identify genetic risk factors contributing to central corneal thickness (CCT) in individ...

Central corneal thickness

Replicated

12664

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-15

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.

Gao X, Nannini DR et al.

Hum Mol Genet

The cornea is the outermost layer of the eye and is a vital component of focusing incoming light on ...

Central corneal thickness

Replicated

4515

Participants

N/A

Studies

Details PubMed

GWAS 2013-03-14

A genome-wide association study of central corneal thickness in Latinos.

Gao X, Gauderman WJ et al.

Invest Ophthalmol Vis Sci

Purpose: Central corneal thickness (CCT) is a clinically important risk factor for primary open-angl...

Central corneal thickness

Replicated

1768

Participants

N/A

Studies

Details PubMed

GWAS 2013-03-11

A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci.

Scheetz TE, Fingert JH et al.

PLoS One

Glaucoma and age-related macular degeneration (AMD) are the two leading causes of visual loss in the...

Age-related macular degeneration

Replicated

797

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-06

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

Lu Y, Vitart V et al.

Nat Genet

Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma...

Corneal structure

20020

Participants

N/A

Studies

Details PubMed

GWAS 2012-07-20

Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.

Hoehn R, Zeller T et al.

Hum Genet

Central corneal thickness (CCT) has become an endophenotype of major interest for the genetically co...

Central corneal thickness

Replicated

5349

Participants

N/A

Studies

Details PubMed

GWAS 2012-06-01

Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.

Ulmer M, Li J et al.

Invest Ophthalmol Vis Sci

Purpose: To investigate the effects of central corneal thickness (CCT)-associated variants on primar...

Central corneal thickness

1117

Participants

N/A

Studies

Details PubMed

GWAS 2010-08-18

New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.

Vitart V, Bencić G et al.

Hum Mol Genet

Central corneal thickness (CCT) is a highly heritable trait, which has been proposed to influence di...

Central corneal thickness

Replicated

7327

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.

Choquet H, Melles RB et al.

Commun Biol

Central corneal thickness

2020-06-11

Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.

Bonnemaijer PWM, Leeuwen EMV et al.

Commun Biol

Optic cup area

2019-11-27

Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.

Ivarsdottir EV, Benonisdottir S et al.

Nat Commun

Corneal hysteresis

2019-03-20

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Iglesias AI, Mishra A et al.

Nat Commun

Central corneal thickness

2018-05-14

Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.

Fan BJ, Chen X et al.

Invest Ophthalmol Vis Sci

Central corneal thickness

2018-05-01

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.

Gao X, Nannini DR et al.

Hum Mol Genet

Central corneal thickness

2016-11-15

A genome-wide association study of central corneal thickness in Latinos.

Gao X, Gauderman WJ et al.

Invest Ophthalmol Vis Sci

Central corneal thickness

2013-03-14

A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci.

Scheetz TE, Fingert JH et al.

PLoS One

Age-related macular degeneration

2013-03-11

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

Lu Y, Vitart V et al.

Nat Genet

Corneal structure

2013-01-06

Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.

Hoehn R, Zeller T et al.

Hum Genet

Central corneal thickness

2012-07-20

Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.

Ulmer M, Li J et al.

Invest Ophthalmol Vis Sci

Central corneal thickness

2012-06-01

New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.

Vitart V, Bencić G et al.

Hum Mol Genet

Central corneal thickness

2010-08-18