Active: Cirrhosis Clear all

GWAS 2024-05-10

A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.

Schwantes-An TH, Whitfield JB et al.

Hepatol Commun

Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect...

Alcohol-associated cirrhosis in heavy drinkers

4305

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-17

Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.

Ghouse J, Sveinbjörnsson G et al.

Nat Genet

We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endop...

Cirrhosis

Replicated

2039708

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-14

Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.

Chen Y, Du X et al.

Nat Genet

Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no effective trea...

Nonalcoholic fatty liver disease

691479

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-04

Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Buch S, Innes H et al.

Gut

Objective: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis ...

Hepatocellular carcinoma in alcohol related cirrhosis

Replicated

3080

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-27

GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.

Ward LD, Tu HC et al.

Nat Commun

Understanding mechanisms of hepatocellular damage may lead to new treatments for liver disease, and ...

Extrahepatic cholangiocarcinoma

408183

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-22

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs.

Cordell HJ, Fryett JJ et al.

J Hepatol

Backgrounds & aims: Primary biliary cholangitis (PBC) is a chronic liver disease in which autoim...

Primary biliary cholangitis

24510

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-18

Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression.

Zeng Z, Liu H et al.

BMC Med Genomics

Recent studies have identified susceptibility genes of HBV clearance, chronic hepatitis B, liver cir...

Persistent hepatitis B virus infection

862

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-18

Genetics of 35 blood and urine biomarkers in the UK Biobank.

Sinnott-Armstrong N, Tanigawa Y et al.

Nat Genet

Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic...

Urinary potassium excretion

345182

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-11

Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians.

Chatterjee A, Basu A et al.

Gene

Non-alcoholic fatty liver disease (NAFLD) is a global epidemic that often progresses to liver cirrho...

Hepatic lipid content

244

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-10

Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study.

Emdin CA, Haas M et al.

Gastroenterology

Background & aims: In contrast to most other common diseases, few genetic variants have been ide...

Cirrhosis (multi-trait analysis)

Replicated

786913

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-01

Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan.

Kamimura S, Tamura A et al.

In Vivo

Background/aim: Hepatitis C virus (HCV) infection is an important health problem in the direct-actin...

Cirrhosis

Replicated

3859

Participants

N/A

Studies

Details PubMed

GWAS 2020-08-27

Genome-wide association study and meta-analysis on alcohol-related liver cirrhosis identifies novel genetic risk factors.

Schwantes-An TH, Darlay R et al.

Hepatology

Background and aims: Only a minority of heavy drinkers progress to alcohol-associated cirrhosis (ALC...

Cirrhosis (alcohol related)

Replicated

14780

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.

Schwantes-An TH, Whitfield JB et al.

Hepatol Commun

Alcohol-associated cirrhosis in heavy drinkers

2024-05-10

Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.

Ghouse J, Sveinbjörnsson G et al.

Nat Genet

Cirrhosis

2024-04-17

Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.

Chen Y, Du X et al.

Nat Genet

Nonalcoholic fatty liver disease

2023-09-14

Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Buch S, Innes H et al.

Gut

Hepatocellular carcinoma in alcohol related cirrhosis

2022-07-04

GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.

Ward LD, Tu HC et al.

Nat Commun

Extrahepatic cholangiocarcinoma

2021-07-27

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs.

Cordell HJ, Fryett JJ et al.

J Hepatol

Primary biliary cholangitis

2021-05-22

Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression.

Zeng Z, Liu H et al.

BMC Med Genomics

Persistent hepatitis B virus infection

2021-03-18

Genetics of 35 blood and urine biomarkers in the UK Biobank.

Sinnott-Armstrong N, Tanigawa Y et al.

Nat Genet

Urinary potassium excretion

2021-01-18

Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians.

Chatterjee A, Basu A et al.

Gene

Hepatic lipid content

2021-01-11

Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study.

Emdin CA, Haas M et al.

Gastroenterology

Cirrhosis (multi-trait analysis)

2020-12-10

Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan.

Kamimura S, Tamura A et al.

In Vivo

Cirrhosis

2020-11-01

Genome-wide association study and meta-analysis on alcohol-related liver cirrhosis identifies novel genetic risk factors.

Schwantes-An TH, Darlay R et al.

Hepatology

Cirrhosis (alcohol related)

2020-08-27