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GWAS 2025-11-05

Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.

Qian Y, Xia J et al.

Genomics Proteomics Bioinformatics

The ultimate goal of a genome-wide association study (GWAS) is to translate its discoveries into cli...

DXA-Bone mineral density (lumbar spine)

30449

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-22

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.

Faber BG, Frysz M et al.

Hum Mol Genet

Objectives: Hip shape is thought to be an important causal risk factor for hip osteoarthritis and fr...

Hip shape mode 1

43485

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-09

Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population.

Vicuña L, Barrientos E et al.

Hum Mol Genet

Early or late pubertal onset can lead to disease in adulthood, including cancer, obesity, type 2 dia...

Tanner 2 to Tanner 3 pubertal stage transition (survival model)

346

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-12

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip fracture predict...

Femoral neck width

38150

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-02

An atlas of genetic determinants of forearm fracture.

Nethander M, Movérare-Skrtic S et al.

Nat Genet

Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, i...

Fracture of forearm

Replicated

1690009

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-24

Genetic correlation, shared loci and causal association between sex hormone-binding globulin and bone mineral density: insights from a large-scale genome-wide cross-trait analysis.

Qu Y, Xiao C et al.

J Bone Miner Res

Although the impact of sex hormones on bone metabolism is well-documented, effect of their primary m...

Sex hormone-binding globulin levels and heel estimated bone mineral density

832949

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-27

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank.

He D, Liu H et al.

Osteoporos Int

Bone mineral density (BMD) is an essential predictor of osteoporosis and fracture. We conducted a ge...

Bone mineral density mean

141261

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-06

Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway.

Mori Y, Ueno K et al.

Int J Mol Sci

This study examined the association between developmental dysplasia of the hip (DDH) and disease-ass...

Developmental dysplasia of the hip

Replicated

79935

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-12

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.

Chen Y, Lu T et al.

Nat Genet

Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome...

Cortolone glucuronide (1) levels

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-01

Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.

Nethander M, Coward E et al.

Cell Rep Med

Hip fracture is the clinically most important fracture, but the genetic architecture of hip fracture...

Hip fracture

735354

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-02

Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.

Yang W, Li L et al.

Commun Biol

Metal elements are present in the human body, and their levels in the blood have important impacts o...

Plasma cadmium levels

656

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-29

Effect of dietary calcium on the gender-specific association between polymorphisms in the PTPRD locus and osteoporosis.

Bae JH, Park D

Clin Nutr

Background & aims: Osteoporosis is the most common bone disease and is characterized by low bone...

Osteoporosis

8842

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.

Qian Y, Xia J et al.

Genomics Proteomics Bioinformatics

DXA-Bone mineral density (lumbar spine)

2025-11-05

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.

Faber BG, Frysz M et al.

Hum Mol Genet

Hip shape mode 1

2024-11-22

Joint models reveal genetic architecture of pubertal stage transitions and their association with BMI in admixed Chilean population.

Vicuña L, Barrientos E et al.

Hum Mol Genet

Tanner 2 to Tanner 3 pubertal stage transition (survival model)

2024-07-09

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width

2024-01-12

An atlas of genetic determinants of forearm fracture.

Nethander M, Movérare-Skrtic S et al.

Nat Genet

Fracture of forearm

2023-11-02

Genetic correlation, shared loci and causal association between sex hormone-binding globulin and bone mineral density: insights from a large-scale genome-wide cross-trait analysis.

Qu Y, Xiao C et al.

J Bone Miner Res

Sex hormone-binding globulin levels and heel estimated bone mineral density

2023-08-24

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank.

He D, Liu H et al.

Osteoporos Int

Bone mineral density mean

2023-07-27

Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway.

Mori Y, Ueno K et al.

Int J Mol Sci

Developmental dysplasia of the hip

2023-03-06

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.

Chen Y, Lu T et al.

Nat Genet

Cortolone glucuronide (1) levels

2023-01-12

Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.

Nethander M, Coward E et al.

Cell Rep Med

Hip fracture

2022-10-01

Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.

Yang W, Li L et al.

Commun Biol

Plasma cadmium levels

2022-05-02

Effect of dietary calcium on the gender-specific association between polymorphisms in the PTPRD locus and osteoporosis.

Bae JH, Park D

Clin Nutr

Osteoporosis

2022-01-29