Active: Glaucoma (primary open-angle) Clear all

GWAS 2024-02-01

Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.

Lo Faro V, Bhattacharya A et al.

Cell Rep Med

Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness globally, shows dispar...

Glaucoma (primary open-angle)

1478037

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-24

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.

Gharahkhani P, Jorgenson E et al.

Nat Commun

Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify...

Glaucoma (primary open-angle)

Replicated

46523

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-14

Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study.

Kim YW, Kim YJ et al.

Sci Rep

Primary open-angle glaucoma (POAG) can develop even within normal ranges of intraocular pressure, an...

Glaucoma (primary open-angle)

Replicated

13300

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-01

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Hauser MA, Allingham RR et al.

JAMA

Importance: Primary open-angle glaucoma presents with increased prevalence and a higher degree of cl...

Glaucoma (primary open-angle)

Replicated

26132

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-13

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.

Bonnemaijer PWM, Iglesias AI et al.

Hum Genet

Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its preva...

Glaucoma (primary open-angle)

Replicated

12070

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-14

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

Restrepo NA, Laper SM et al.

BMC Med Genomics

Glaucoma is a leading cause of blindness in developed countries. Primary open-angle glaucoma (POAG),...

Glaucoma (primary open-angle)

1514

Participants

N/A

Studies

Details PubMed

GWAS 2018-06-11

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

Choquet H, Paylakhi S et al.

Nat Commun

Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the g...

Glaucoma (primary open-angle)

Replicated

240302

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-14

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.

Shiga Y, Akiyama M et al.

Hum Mol Genet

Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for whic...

Glaucoma (primary open-angle)

Replicated

90220

Participants

N/A

Studies

Details PubMed

GWAS 2016-09-13

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.

Verma SS, Cooke Bailey JN et al.

PLoS Genet

Primary open angle glaucoma (POAG) is a complex disease and is one of the major leading causes of bl...

Glaucoma (primary open-angle)

5090

Participants

N/A

Studies

Details PubMed

GWAS 2016-03-22

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Vishal M, Sharma A et al.

BMC Med Genomics

Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people global...

Glaucoma (primary open-angle)

Replicated

1317

Participants

N/A

Studies

Details PubMed

GWAS 2016-01-11

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.

Bailey JN, Loomis SJ et al.

Nat Genet

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To identify new suscep...

Glaucoma (primary open-angle)

Replicated

49749

Participants

N/A

Studies

Details PubMed

GWAS 2015-04-10

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Li Z, Allingham RR et al.

Hum Mol Genet

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with ...

Glaucoma (primary open-angle)

Replicated

49203

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.

Lo Faro V, Bhattacharya A et al.

Cell Rep Med

Glaucoma (primary open-angle)

2024-02-01

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.

Gharahkhani P, Jorgenson E et al.

Nat Commun

Glaucoma (primary open-angle)

2021-02-24

Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study.

Kim YW, Kim YJ et al.

Sci Rep

Glaucoma (primary open-angle)

2020-01-14

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Hauser MA, Allingham RR et al.

JAMA

Glaucoma (primary open-angle)

2019-11-01

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.

Bonnemaijer PWM, Iglesias AI et al.

Hum Genet

Glaucoma (primary open-angle)

2018-10-13

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

Restrepo NA, Laper SM et al.

BMC Med Genomics

Glaucoma (primary open-angle)

2018-09-14

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

Choquet H, Paylakhi S et al.

Nat Commun

Glaucoma (primary open-angle)

2018-06-11

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.

Shiga Y, Akiyama M et al.

Hum Mol Genet

Glaucoma (primary open-angle)

2018-02-14

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.

Verma SS, Cooke Bailey JN et al.

PLoS Genet

Glaucoma (primary open-angle)

2016-09-13

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Vishal M, Sharma A et al.

BMC Med Genomics

Glaucoma (primary open-angle)

2016-03-22

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.

Bailey JN, Loomis SJ et al.

Nat Genet

Glaucoma (primary open-angle)

2016-01-11

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Li Z, Allingham RR et al.

Hum Mol Genet

Glaucoma (primary open-angle)

2015-04-10