Active: Hemoglobin concentration Clear all

GWAS 2022-08-11

Common and Ethnic-Specific Genetic Determinants of Hemoglobin Concentration between Taiwanese Han Chinese and European Whites: Findings from Comparative Two-Stage Genome-Wide Association Studies.

Timoteo VJ, Chiang KM et al.

J Nutr Biochem

Human iron nutrition is a result of interplays between genetic and environmental factors. However, t...

Hemoglobin concentration

Replicated

41694

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-21

Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.

Hu Y, Stilp AM et al.

Am J Hum Genet

Whole-genome sequencing (WGS), a powerful tool for detecting novel coding and non-coding disease-cau...

Hematocrit

62487

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-23

Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis.

Oskarsson GR, Oddsson A et al.

Commun Biol

Hemoglobin is the essential oxygen-carrying molecule in humans and is regulated by cellular iron and...

Hemoglobin levels

684122

Participants

N/A

Studies

Details PubMed

GWAS 2017-05-13

Genome-wide association study of erythrocyte density in sickle cell disease patients.

Ilboudo Y, Bartolucci P et al.

Blood Cells Mol Dis

Deoxy-hemoglobin S polymerization into rigid fibers is the direct cause of the clinical sequelae obs...

Mean corpuscular hemoglobin concentration in sickle cell disease

317

Participants

N/A

Studies

Details PubMed

GWAS 2014-04-28

Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits.

Auer PL, Teumer A et al.

Nat Genet

Hematological traits are important clinical parameters. To test the effects of rare and low-frequenc...

Platelet count

Replicated

31340

Participants

N/A

Studies

Details PubMed

GWAS 2013-07-31

Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.

Pistis G, Okonkwo SU et al.

PLoS One

The red blood cell related traits are highly heritable but their genetics are poorly defined. Only 5...

Red blood cell traits

Replicated

18428

Participants

N/A

Studies

Details PubMed

GWAS 2013-05-20

Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study.

Ding K, de Andrade M et al.

G3 (Bethesda)

To identify novel genetic loci influencing interindividual variation in red blood cell (RBC) traits ...

Red blood cell traits

Replicated

2315

Participants

N/A

Studies

Details PubMed

GWAS 2012-12-20

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.

Li J, Glessner JT et al.

Hum Mol Genet

Hematological traits are important clinical indicators, the genetic determinants of which have not b...

Mean corpuscular hemoglobin

14177

Participants

N/A

Studies

Details PubMed

GWAS 2010-12-31

Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.

Okada Y, Takahashi A et al.

Hum Mol Genet

C-reactive protein (CRP) is a hallmark acute-phase reactant and is widely used as a blood marker for...

C-reactive protein

Replicated

12854

Participants

N/A

Studies

Details PubMed

GWAS 2010-06-22

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.

Beall CM, Cavalleri GL et al.

Proc Natl Acad Sci U S A

By impairing both function and survival, the severe reduction in oxygen availability associated with...

Hemoglobin levels

Replicated

196

Participants

N/A

Studies

Details PubMed

GWAS 2009-12-16

Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.

Solovieff N, Milton JN et al.

Blood

In a genome-wide association study of 848 blacks with sickle cell anemia, we identified single nucle...

Fetal hemoglobin levels

Replicated

1672

Participants

N/A

Studies

Details PubMed

GWAS 2009-10-11

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

Chambers JC, Zhang W et al.

Nat Genet

We carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of Europea...

Hemoglobin

Replicated

27909

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Common and Ethnic-Specific Genetic Determinants of Hemoglobin Concentration between Taiwanese Han Chinese and European Whites: Findings from Comparative Two-Stage Genome-Wide Association Studies.

Timoteo VJ, Chiang KM et al.

J Nutr Biochem

Hemoglobin concentration

2022-08-11

Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.

Hu Y, Stilp AM et al.

Am J Hum Genet

Hematocrit

2021-04-21

Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis.

Oskarsson GR, Oddsson A et al.

Commun Biol

Hemoglobin levels

2020-04-23

Genome-wide association study of erythrocyte density in sickle cell disease patients.

Ilboudo Y, Bartolucci P et al.

Blood Cells Mol Dis

Mean corpuscular hemoglobin concentration in sickle cell disease

2017-05-13

Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits.

Auer PL, Teumer A et al.

Nat Genet

Platelet count

2014-04-28

Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.

Pistis G, Okonkwo SU et al.

PLoS One

Red blood cell traits

2013-07-31

Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study.

Ding K, de Andrade M et al.

G3 (Bethesda)

Red blood cell traits

2013-05-20

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.

Li J, Glessner JT et al.

Hum Mol Genet

Mean corpuscular hemoglobin

2012-12-20

Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.

Okada Y, Takahashi A et al.

Hum Mol Genet

C-reactive protein

2010-12-31

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.

Beall CM, Cavalleri GL et al.

Proc Natl Acad Sci U S A

Hemoglobin levels

2010-06-22

Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.

Solovieff N, Milton JN et al.

Blood

Fetal hemoglobin levels

2009-12-16

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

Chambers JC, Zhang W et al.

Nat Genet

Hemoglobin

2009-10-11