Active: Hepatocellular carcinoma Clear all

GWAS 2024-04-17

Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.

Ghouse J, Sveinbjörnsson G et al.

Nat Genet

We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endop...

Cirrhosis

Replicated

2039708

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-14

Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.

Chen Y, Du X et al.

Nat Genet

Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no effective trea...

Nonalcoholic fatty liver disease

691479

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-04

Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Buch S, Innes H et al.

Gut

Objective: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis ...

Hepatocellular carcinoma in alcohol related cirrhosis

Replicated

3080

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-09

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.

Shen T, Ni T et al.

Nat Commun

Most cancer causal variants are found in gene regulatory elements, e.g., enhancers. However, enhance...

Hepatocellular carcinoma

Replicated

11958

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-11

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study.

Trépo E, Caruso S et al.

Lancet Oncol

Hepatocellular carcinoma is a frequent consequence of alcohol-related liver disease, with variable i...

Alcohol-related hepatocellular carcinoma

2107

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-18

Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression.

Zeng Z, Liu H et al.

BMC Med Genomics

Recent studies have identified susceptibility genes of HBV clearance, chronic hepatitis B, liver cir...

Persistent hepatitis B virus infection

862

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-11

Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians.

Chatterjee A, Basu A et al.

Gene

Non-alcoholic fatty liver disease (NAFLD) is a global epidemic that often progresses to liver cirrho...

Hepatic lipid content

244

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-01

Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan.

Kamimura S, Tamura A et al.

In Vivo

Background/aim: Hepatitis C virus (HCV) infection is an important health problem in the direct-actin...

Cirrhosis

Replicated

3859

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-10

Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.

Chen QY, Hu YL et al.

Int J Med Sci

The basal core promoter (BCP) double mutations (A1762T and G1764A) of hepatitis B virus (HBV) have b...

Viral basal core promoter double mutation in hepatitis B virus surface antigen (HBsAg) seropositivity

Replicated

793

Participants

N/A

Studies

Details PubMed

GWAS 2019-04-04

Genome-Wide Association Study Identifies a Genetic Prediction Model for Postoperative Survival in Patients with Hepatocellular Carcinoma.

Wei J, Sheng Y et al.

Med Sci Monit

BACKGROUND As an important aspect of tumor heterogeneity, genetic variation may influence susceptibi...

Postoperative survival time in hepatocellular carcinoma

Replicated

1125

Participants

N/A

Studies

Details PubMed

GWAS 2019-03-01

Genomewide association study for C-reactive protein in Indians replicates known associations of common variants.

Prasad G, Giri AK et al.

J Genet

Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammat...

Postoperative survival time in hepatocellular carcinoma

Replicated

1125

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-18

Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome-Wide Association Study.

Yang C, Han C et al.

J Oncol

NM23 expression is closely associated with hepatocellular carcinoma (HCC) recurrence, but the heredi...

Nucleoside diphosphate kinase A levels in hepatocellular carcinoma

408

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.

Ghouse J, Sveinbjörnsson G et al.

Nat Genet

Cirrhosis

2024-04-17

Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.

Chen Y, Du X et al.

Nat Genet

Nonalcoholic fatty liver disease

2023-09-14

Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Buch S, Innes H et al.

Gut

Hepatocellular carcinoma in alcohol related cirrhosis

2022-07-04

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.

Shen T, Ni T et al.

Nat Commun

Hepatocellular carcinoma

2022-03-09

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study.

Trépo E, Caruso S et al.

Lancet Oncol

Alcohol-related hepatocellular carcinoma

2021-12-11

Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression.

Zeng Z, Liu H et al.

BMC Med Genomics

Persistent hepatitis B virus infection

2021-03-18

Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians.

Chatterjee A, Basu A et al.

Gene

Hepatic lipid content

2021-01-11

Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan.

Kamimura S, Tamura A et al.

In Vivo

Cirrhosis

2020-11-01

Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.

Chen QY, Hu YL et al.

Int J Med Sci

Viral basal core promoter double mutation in hepatitis B virus surface antigen (HBsAg) seropositivity

2019-06-10

Genome-Wide Association Study Identifies a Genetic Prediction Model for Postoperative Survival in Patients with Hepatocellular Carcinoma.

Wei J, Sheng Y et al.

Med Sci Monit

Postoperative survival time in hepatocellular carcinoma

2019-04-04

Genomewide association study for C-reactive protein in Indians replicates known associations of common variants.

Prasad G, Giri AK et al.

J Genet

Postoperative survival time in hepatocellular carcinoma

2019-03-01

Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome-Wide Association Study.

Yang C, Han C et al.

J Oncol

Nucleoside diphosphate kinase A levels in hepatocellular carcinoma

2018-12-18