Active: Hip fracture Clear all

GWAS 2024-01-12

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip fracture predict...

Femoral neck width

38150

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-02

An atlas of genetic determinants of forearm fracture.

Nethander M, Movérare-Skrtic S et al.

Nat Genet

Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, i...

Fracture of forearm

Replicated

1690009

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-12

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.

Chen Y, Lu T et al.

Nat Genet

Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome...

Cortolone glucuronide (1) levels

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-01

Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.

Nethander M, Coward E et al.

Cell Rep Med

Hip fracture is the clinically most important fracture, but the genetic architecture of hip fracture...

Hip fracture

735354

Participants

N/A

Studies

Details PubMed

GWAS 2019-05-03

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.

Styrkarsdottir U, Stefansson OA et al.

Nat Commun

Bone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (...

Femoral neck size

Replicated

44688

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-15

Identification of novel loci associated with hip shape: a meta-analysis of genome-wide association studies.

Baird DA, Evans DS et al.

J Bone Miner Res

We aimed to report the first genomewide association study (GWAS) meta-analysis of dual-energy X-ray ...

Hip shape (DXA scan)

15934

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-09

Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density at forearm.

Zheng HF, Duncan EL et al.

J Med Genet

Forearm fractures affect 1.7 million individuals worldwide each year and most occur earlier in life ...

Bone mineral density

Replicated

6581

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-04

Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche.

Ran S, Pei YF et al.

PLoS One

Femoral neck geometric parameters (FNGPs), which include cortical thickness (CT), periosteal diamete...

Femoral neck bone geometry and menarche (age at onset)

Replicated

3055

Participants

N/A

Studies

Details PubMed

GWAS 2012-08-31

Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.

Han Y, Pei Y et al.

Bone

Compressive strength index (CSI) is a newly established index for predicting hip fracture, the most ...

Comprehensive strength and appendicular lean mass

Replicated

4913

Participants

N/A

Studies

Details PubMed

GWAS 2009-12-11

Genome-wide association study for femoral neck bone geometry.

Zhao LJ, Liu XG et al.

J Bone Miner Res

Poor femoral neck bone geometry at the femur is an important risk factor for hip fracture. We conduc...

Femoral neck bone geometry

Replicated

4593

Participants

N/A

Studies

Details PubMed

GWAS 2009-02-25

Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.

Xiong DH, Liu XG et al.

Am J Hum Genet

To identify and validate genes associated with bone mineral density (BMD), which is a prominent oste...

Bone mineral density

Replicated

10488

Participants

N/A

Studies

Details PubMed

GWAS 2008-09-08

Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study.

Liu YZ, Wilson SG et al.

PLoS One

Osteoporosis, the most prevalent metabolic bone disease among older people, increases risk for low t...

Hip bone size

Replicated

2216

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width

2024-01-12

An atlas of genetic determinants of forearm fracture.

Nethander M, Movérare-Skrtic S et al.

Nat Genet

Fracture of forearm

2023-11-02

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.

Chen Y, Lu T et al.

Nat Genet

Cortolone glucuronide (1) levels

2023-01-12

Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.

Nethander M, Coward E et al.

Cell Rep Med

Hip fracture

2022-10-01

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.

Styrkarsdottir U, Stefansson OA et al.

Nat Commun

Femoral neck size

2019-05-03

Identification of novel loci associated with hip shape: a meta-analysis of genome-wide association studies.

Baird DA, Evans DS et al.

J Bone Miner Res

Hip shape (DXA scan)

2018-10-15

Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density at forearm.

Zheng HF, Duncan EL et al.

J Med Genet

Bone mineral density

2013-04-09

Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche.

Ran S, Pei YF et al.

PLoS One

Femoral neck bone geometry and menarche (age at onset)

2013-04-04

Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.

Han Y, Pei Y et al.

Bone

Comprehensive strength and appendicular lean mass

2012-08-31

Genome-wide association study for femoral neck bone geometry.

Zhao LJ, Liu XG et al.

J Bone Miner Res

Femoral neck bone geometry

2009-12-11

Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.

Xiong DH, Liu XG et al.

Am J Hum Genet

Bone mineral density

2009-02-25

Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study.

Liu YZ, Wilson SG et al.

PLoS One

Hip bone size

2008-09-08