Active: Hypertension Clear all

GWAS 2025-11-09

Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population.

Jo J, Ha N et al.

Genomics Proteomics Bioinformatics

We conducted a comprehensive genetic investigation of obesity in a cohort of 93,673 Korean individua...

Body mass index

Replicated

484808

Participants

N/A

Studies

Details PubMed

GWAS 2025-09-26

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Genetic predisposition to central adiposity is associated with metabolic dysfunction and obesity-rel...

Waist circumference

49188

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-13

Beyond volume: Unraveling the genetics of human brain geometry.

Primus SA, Hoffstaedter F et al.

Sci Adv

Brain geometry affects brain function. A quantitative encoding of form is provided by the Laplace-Be...

Left accumbens area shape (Laplace-Beltrami spectrum)

Replicated

24823

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-04

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

Nagarajan P, Winkler TW et al.

Mol Psychiatry

Although both short and long sleep duration are associated with elevated hypertension risk, our unde...

Systolic blood pressure x short total sleep time interaction (main effect)

810633

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-21

Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.

Borges VM, Horimoto ARVR et al.

J Am Heart Assoc

Essential hypertension (EH) is a global health issue. Despite extensive research, much of EH heritab...

Essential hypertension

431

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-28

Associations between common genetic variants and income provide insights about the socio-economic health gradient.

Kweon H, Burik CAP et al.

Nat Hum Behav

We conducted a genome-wide association study on income among individuals of European descent (N = 66...

Individual income

72601

Participants

N/A

Studies

Details PubMed

GWAS 2024-12-10

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

While brainstem regions are central regulators of blood pressure, the neuronal mechanisms underlying...

Systolic blood pressure

174014

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-15

Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.

Teixeira SK, Rossi FPN et al.

Sci Rep

Despite the identification of numerous genetic variants affecting SBP in European populations, their...

Systolic blood pressure

286581

Participants

N/A

Studies

Details PubMed

GWAS 2024-08-20

Mid-pass Whole-genome Sequencing in a Malagasy Cohort Uncovers Body Composition Associations.

Hamid I, Raveloson SNS et al.

HGG Adv

The majority of human genomic research studies have been conducted in European-ancestry cohorts, red...

Basal metabolic rate

214

Participants

N/A

Studies

Details PubMed

GWAS 2024-08-15

The genetic architecture of age at menarche and its causal effects on other traits.

Feng GJ, Xu Q et al.

J Hum Genet

Age at menarche (AAM) is a sign of puberty of females. It is a heritable trait associated with vario...

Age at menarche

371060

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-18

Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.

Zhukovsky P, Tio ES et al.

Nat Commun

Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related...

Global cortical thickness (GlobalMeanMean)

34552

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-30

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

Keaton JM, Kamali Z et al.

Nat Genet

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, report...

Systolic blood pressure

Replicated

1091027

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Association of Multiple-trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean Population.

Jo J, Ha N et al.

Genomics Proteomics Bioinformatics

Body mass index

2025-11-09

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Waist circumference

2025-09-26

Beyond volume: Unraveling the genetics of human brain geometry.

Primus SA, Hoffstaedter F et al.

Sci Adv

Left accumbens area shape (Laplace-Beltrami spectrum)

2025-06-13

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

Nagarajan P, Winkler TW et al.

Mol Psychiatry

Systolic blood pressure x short total sleep time interaction (main effect)

2025-04-04

Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.

Borges VM, Horimoto ARVR et al.

J Am Heart Assoc

Essential hypertension

2025-03-21

Associations between common genetic variants and income provide insights about the socio-economic health gradient.

Kweon H, Burik CAP et al.

Nat Hum Behav

Individual income

2025-01-28

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

Systolic blood pressure

2024-12-10

Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.

Teixeira SK, Rossi FPN et al.

Sci Rep

Systolic blood pressure

2024-11-15

Mid-pass Whole-genome Sequencing in a Malagasy Cohort Uncovers Body Composition Associations.

Hamid I, Raveloson SNS et al.

HGG Adv

Basal metabolic rate

2024-08-20

The genetic architecture of age at menarche and its causal effects on other traits.

Feng GJ, Xu Q et al.

J Hum Genet

Age at menarche

2024-08-15

Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.

Zhukovsky P, Tio ES et al.

Nat Commun

Global cortical thickness (GlobalMeanMean)

2024-06-18

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

Keaton JM, Kamali Z et al.

Nat Genet

Systolic blood pressure

2024-04-30