Active: Liver fat Clear all

GWAS 2025-06-02

Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition.

Ahmad S, Carrasquilla GD et al.

JHEP Rep

Background & aims: A quarter of the world population is estimated to have metabolic dysfunction-...

Liver fat

27243

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-19

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition.

van der Meer D, Gurholt TP et al.

Commun Biol

Obesity and associated morbidities, metabolic associated fatty liver disease (MAFLD) included, const...

Abdominal subcutaneous adipose tissue

33532

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-01

Machine learning enables new insights into genetic contributions to liver fat accumulation.

Haas ME, Pirruccello JP et al.

Cell Genom

Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease and...

Liver fat

Replicated

40453

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-12

Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease.

Martin S, Cule M et al.

Diabetes

To understand the causal role of adiposity and ectopic fat in type 2 diabetes and cardiometabolic di...

Body fat percentage

442278

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-06

Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome-wide association and Mendelian randomization study.

Zeng H, Ge J et al.

J Bone Miner Res

Recent advances indicate that bone and energy metabolism are closely related. However, little direct...

Serum 25-Hydroxyvitamin D levels

Replicated

4665

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-25

Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study.

Park SL, Li Y et al.

Hepatol Commun

The global rise in fatty liver is a major public health problem. Thus, it is critical to identify bo...

Nonalcoholic fatty liver disease

1529

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-02

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.

Parisinos CA, Wilman HR et al.

J Hepatol

Background & aims: MRI-based corrected T1 (cT1) is a non-invasive method to grade the severity o...

Liver fat content (MRI proton density fat fraction measure)

14440

Participants

N/A

Studies

Details PubMed

GWAS 2017-10-30

Exome-wide association study of plasma lipids in >300,000 individuals.

Liu DJ, Peloso GM et al.

Nat Genet

We screened variants on an exome-focused genotyping array in >300,000 participants (replication i...

Total cholesterol levels

Replicated

584092

Participants

N/A

Studies

Details PubMed

GWAS 2014-02-16

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.

Kozlitina J, Smagris E et al.

Nat Genet

Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. To elucidate the ...

Nonalcoholic fatty liver disease

4707

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Impact of genetic variants linked to liver fat and liver volume on MRI-mapped body composition.

Ahmad S, Carrasquilla GD et al.

JHEP Rep

Liver fat

2025-06-02

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition.

van der Meer D, Gurholt TP et al.

Commun Biol

Abdominal subcutaneous adipose tissue

2022-11-19

Machine learning enables new insights into genetic contributions to liver fat accumulation.

Haas ME, Pirruccello JP et al.

Cell Genom

Liver fat

2021-12-01

Genetic evidence for different adiposity phenotypes and their opposing influence on ectopic fat and risk of cardiometabolic disease.

Martin S, Cule M et al.

Diabetes

Body fat percentage

2021-05-12

Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome-wide association and Mendelian randomization study.

Zeng H, Ge J et al.

J Bone Miner Res

Serum 25-Hydroxyvitamin D levels

2021-05-06

Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study.

Park SL, Li Y et al.

Hepatol Commun

Nonalcoholic fatty liver disease

2020-06-25

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.

Parisinos CA, Wilman HR et al.

J Hepatol

Liver fat content (MRI proton density fat fraction measure)

2020-04-02

Exome-wide association study of plasma lipids in >300,000 individuals.

Liu DJ, Peloso GM et al.

Nat Genet

Total cholesterol levels

2017-10-30

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.

Kozlitina J, Smagris E et al.

Nat Genet

Nonalcoholic fatty liver disease

2014-02-16