Active: Lung adenocarcinoma Clear all

GWAS 2025-05-08

Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.

Byun J, Han Y et al.

Hum Mol Genet

Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and m...

Lung adenocarcinoma

5274

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-04

Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

Gorman BR, Ji SG et al.

Nat Commun

Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous...

Lung cancer

Replicated

260154

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-26

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Shi J, Shiraishi K et al.

Nat Commun

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small...

Lung adenocarcinoma

Replicated

172334

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-03

Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population.

Chang X, Gurung RL et al.

Commun Biol

The role of low frequency variants associated with telomere length homeostasis in chronic diseases a...

Telomere length

Replicated

25473

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-05

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.

Qin N, Li Y et al.

Front Med

Although genome-wide association studies have identified more than eighty genetic variants associate...

Lung adenocarcinoma

42936

Participants

N/A

Studies

Details PubMed

GWAS 2017-06-12

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

McKay JD, Hung RJ et al.

Nat Genet

Although several lung cancer susceptibility loci have been identified, much of the heritability for ...

Lung cancer

85716

Participants

N/A

Studies

Details PubMed

GWAS 2016-09-26

Genetic Modifiers of Progression-Free Survival in Never-Smoking Lung Adenocarcinoma Patients Treated with First-Line Tyrosine Kinase Inhibitors.

Chang IS, Jiang SS et al.

Am J Respir Crit Care Med

Rationale: Patients with non-small cell lung cancer (NSCLC) with mutated epidermal growth factor rec...

Progression free survival in EGFR-mutation-positive never-smoking lung adenocarcinoma treated with gefitinib or erlotinib

Replicated

351

Participants

N/A

Studies

Details PubMed

GWAS 2016-08-09

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.

Shiraishi K, Okada Y et al.

Nat Commun

Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than ...

EGFR mutation-positive lung adenocarcinoma

Replicated

18331

Participants

N/A

Studies

Details PubMed

GWAS 2016-04-20

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Fehringer G, Kraft P et al.

Cancer Res

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing m...

Cancer (pleiotropy)

123671

Participants

N/A

Studies

Details PubMed

GWAS 2014-06-01

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.

Wang Y, McKay JD et al.

Nat Genet

We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung ...

Lung cancer

Replicated

75750

Participants

N/A

Studies

Details PubMed

GWAS 2012-07-15

A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.

Shiraishi K, Kunitoh H et al.

Nat Genet

Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increa...

Lung adenocarcinoma

Replicated

19564

Participants

N/A

Studies

Details PubMed

GWAS 2011-01-17

Multiple genetic loci modulate lung adenocarcinoma clinical staging.

Frullanti E, Galvan A et al.

Clin Cancer Res

Purpose: The main prognostic factor of lung cancer patient outcome is clinical stage, a parameter of...

Lung adenocarcinoma (clinical stage)

Replicated

917

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.

Byun J, Han Y et al.

Hum Mol Genet

Lung adenocarcinoma

2025-05-08

Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

Gorman BR, Ji SG et al.

Nat Commun

Lung cancer

2024-10-04

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Shi J, Shiraishi K et al.

Nat Commun

Lung adenocarcinoma

2023-05-26

Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population.

Chang X, Gurung RL et al.

Commun Biol

Telomere length

2021-05-03

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.

Qin N, Li Y et al.

Front Med

Lung adenocarcinoma

2020-09-05

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

McKay JD, Hung RJ et al.

Nat Genet

Lung cancer

2017-06-12

Genetic Modifiers of Progression-Free Survival in Never-Smoking Lung Adenocarcinoma Patients Treated with First-Line Tyrosine Kinase Inhibitors.

Chang IS, Jiang SS et al.

Am J Respir Crit Care Med

Progression free survival in EGFR-mutation-positive never-smoking lung adenocarcinoma treated with gefitinib or erlotinib

2016-09-26

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.

Shiraishi K, Okada Y et al.

Nat Commun

EGFR mutation-positive lung adenocarcinoma

2016-08-09

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Fehringer G, Kraft P et al.

Cancer Res

Cancer (pleiotropy)

2016-04-20

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.

Wang Y, McKay JD et al.

Nat Genet

Lung cancer

2014-06-01

A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.

Shiraishi K, Kunitoh H et al.

Nat Genet

Lung adenocarcinoma

2012-07-15

Multiple genetic loci modulate lung adenocarcinoma clinical staging.

Frullanti E, Galvan A et al.

Clin Cancer Res

Lung adenocarcinoma (clinical stage)

2011-01-17