Active: Lung cancer Clear all

GWAS 2025-09-01

Regulatory polymorphisms of MSH6, MSH2, FBXO11, and PPP1R21 genes affect survival of patients with immunotherapy-treated lung cancer.

Esposito M, Noci S et al.

J Immunother Cancer

Immune checkpoint inhibitors (ICI) improved survival of patients with non-small cell lung cancer (NS...

Overall survival in non-small lung cancer treated with immune checkpoint inhibitors

150

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-13

Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.

Betti MJ, Jaworski J et al.

Am J Hum Genet

Striking disparities in lung cancer exist, with Black/African American individuals disproportionatel...

Lung cancer

6490

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-09

Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese.

Zhou D, Wu M et al.

Nat Commun

A substantial portion of lung cancer-associated genetic elements in East Asian populations remains u...

Non-small cell lung cancer

Replicated

13722

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-01

Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium.

Dong M, Thakral A et al.

Carcinogenesis

Lung cancer is the leading cause of cancer mortality. To investigate genetic determinants for progno...

Late-stage non-small cell lung cancer

Replicated

3916

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-08

Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.

Byun J, Han Y et al.

Hum Mol Genet

Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and m...

Lung adenocarcinoma

5274

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-04

Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

Gorman BR, Ji SG et al.

Nat Commun

Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous...

Lung cancer

Replicated

260154

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-05

Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.

Boumtje V, Manikpurage HD et al.

EBioMedicine

The most near-term clinical application of genome-wide association studies in lung cancer is a polyg...

Lung cancer

24012

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-20

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.

Levey DF, Galimberti M et al.

Nat Genet

As recreational use of cannabis is being decriminalized in many places and medical use widely sancti...

Cannabis use disorder

38289

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-17

Development and evaluation of a polygenic risk score for lung cancer in never-smoking women: A large-scale prospective Chinese cohort study.

Wei X, Sun D et al.

Int J Cancer

The proportion of lung cancer in never smokers is rising, especially among Asian women, but there is...

Lung cancer in never smokers

16870

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-02

Machine Learning Study of SNPs in Noncoding Regions to Predict Non-small Cell Lung Cancer Susceptibility.

Huang Y, Bao T et al.

Clin Oncol (R Coll Radiol)

Non-small cell lung cancer (NSCLC) is the most common pathological subtype of lung cancer. Both envi...

Non-small cell lung cancer

726

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-20

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.

Sato G, Shirai Y et al.

Nat Commun

Integrating genomic data of multiple cancers allows de novo cancer grouping and elucidating the shar...

Ovarian cancer

Replicated

336340

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-26

A two-stage genome-wide association study identified four potential early-onset nonsmall cell lung cancer risk loci based on 26,652 participants in Chinese population.

Fan J, Hong T et al.

Mol Carcinog

Early-onset lung cancer is rare with an increasing incidence rate. Although several genetic variants...

Early onset non-small cell lung cancer

15883

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Regulatory polymorphisms of MSH6, MSH2, FBXO11, and PPP1R21 genes affect survival of patients with immunotherapy-treated lung cancer.

Esposito M, Noci S et al.

J Immunother Cancer

Overall survival in non-small lung cancer treated with immune checkpoint inhibitors

2025-09-01

Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.

Betti MJ, Jaworski J et al.

Am J Hum Genet

Lung cancer

2025-08-13

Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese.

Zhou D, Wu M et al.

Nat Commun

Non-small cell lung cancer

2025-08-09

Genome-wide association study of early-stage non-small cell lung cancer prognosis: a pooled analysis in the International Lung Cancer Consortium.

Dong M, Thakral A et al.

Carcinogenesis

Late-stage non-small cell lung cancer

2025-08-01

Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.

Byun J, Han Y et al.

Hum Mol Genet

Lung adenocarcinoma

2025-05-08

Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

Gorman BR, Ji SG et al.

Nat Commun

Lung cancer

2024-10-04

Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.

Boumtje V, Manikpurage HD et al.

EBioMedicine

Lung cancer

2024-07-05

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.

Levey DF, Galimberti M et al.

Nat Genet

Cannabis use disorder

2023-11-20

Development and evaluation of a polygenic risk score for lung cancer in never-smoking women: A large-scale prospective Chinese cohort study.

Wei X, Sun D et al.

Int J Cancer

Lung cancer in never smokers

2023-10-17

Machine Learning Study of SNPs in Noncoding Regions to Predict Non-small Cell Lung Cancer Susceptibility.

Huang Y, Bao T et al.

Clin Oncol (R Coll Radiol)

Non-small cell lung cancer

2023-09-02

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.

Sato G, Shirai Y et al.

Nat Commun

Ovarian cancer

2023-06-20

A two-stage genome-wide association study identified four potential early-onset nonsmall cell lung cancer risk loci based on 26,652 participants in Chinese population.

Fan J, Hong T et al.

Mol Carcinog

Early onset non-small cell lung cancer

2023-05-26