Active: Major depressive disorder Clear all

GWAS 2025-11-13

Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression.

Shorter JR, Pasman JA et al.

Nat Genet

Major depressive disorder (MDD) is a common and heterogeneous disorder of complex etiology. Studying...

Early onset major depressive disorder

153532

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-26

Sex-stratified genome-wide association meta-analysis of major depressive disorder.

Thomas JT, Thorp JG et al.

Nat Commun

There are striking sex differences in the prevalence and symptomology of Major Depressive Disorder. ...

Major depressive disorder

Replicated

295754

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-10

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics.

Lo CWH, Gillett AC et al.

Biol Psychiatry Glob Open Sci

Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major de...

SSRI switching

36334

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-01

Sex-Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome-Wide Association Study of All of Us and UK Biobank Data.

Hu Y, Che M et al.

Genet Epidemiol

Major depressive disorder (MDD) is prevalent worldwide, substantially and negatively impacting both ...

Major depressive disorder

Replicated

569098

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-20

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Chen TT, Chen CY et al.

Mol Psychiatry

Childhood maltreatment is increasingly recognized as a pivotal risk factor for adverse health outcom...

Physical neglect

129017

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-06

Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes.

Li M, Dang X et al.

Nat Commun

Since the birth of cognitive science, researchers have used reaction time and accuracy to measure co...

Cognitive processing speed

2266733

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-10

Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization.

Marchi M, Alkema A et al.

Nat Hum Behav

It is unclear whether poverty and mental illness are causally related. Using UK Biobank and Psychiat...

Poverty (general factor)

453689

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-11

Shared genetic effect of kidney function on bipolar and major depressive disorders: a large-scale genome-wide cross-trait analysis.

Yu S, Lin Y et al.

Hum Genomics

Epidemiological studies have revealed a significant association between impaired kidney function and...

Bipolar disorder or blood urea nitrogen levels (MTAG)

904388

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-01

Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study.

Tebeka S, Gloaguen E et al.

Eur Psychiatry

Postpartum depression (PPD) appears at two peak periods: early-onset prior to 2 months after deliver...

Early-onset postpartum depression

1438

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-15

Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.

Bigdeli TB, Barr PB et al.

Mol Psychiatry

Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-inj...

Suicide behaviour in schizophrenia

5334

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-15

Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory.

Ohseto H, Takahashi I et al.

Depress Anxiety

This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic ar...

Perinatal depression

5098

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-13

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder.

Nuñez NA, Coombes BJ et al.

Transl Psychiatry

There is increasing interest in individualizing treatment selection for more than 25 regulatory appr...

Antidepressant-associated treatment emergent mania in BD

861

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression.

Shorter JR, Pasman JA et al.

Nat Genet

Early onset major depressive disorder

2025-11-13

Sex-stratified genome-wide association meta-analysis of major depressive disorder.

Thomas JT, Thorp JG et al.

Nat Commun

Major depressive disorder

2025-08-26

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics.

Lo CWH, Gillett AC et al.

Biol Psychiatry Glob Open Sci

SSRI switching

2025-04-10

Sex-Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome-Wide Association Study of All of Us and UK Biobank Data.

Hu Y, Che M et al.

Genet Epidemiol

Major depressive disorder

2025-04-01

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Chen TT, Chen CY et al.

Mol Psychiatry

Physical neglect

2025-02-20

Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes.

Li M, Dang X et al.

Nat Commun

Cognitive processing speed

2024-09-06

Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization.

Marchi M, Alkema A et al.

Nat Hum Behav

Poverty (general factor)

2024-07-10

Shared genetic effect of kidney function on bipolar and major depressive disorders: a large-scale genome-wide cross-trait analysis.

Yu S, Lin Y et al.

Hum Genomics

Bipolar disorder or blood urea nitrogen levels (MTAG)

2024-06-11

Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study.

Tebeka S, Gloaguen E et al.

Eur Psychiatry

Early-onset postpartum depression

2024-04-01

Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.

Bigdeli TB, Barr PB et al.

Mol Psychiatry

Suicide behaviour in schizophrenia

2024-03-15

Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory.

Ohseto H, Takahashi I et al.

Depress Anxiety

Perinatal depression

2024-03-15

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder.

Nuñez NA, Coombes BJ et al.

Transl Psychiatry

Antidepressant-associated treatment emergent mania in BD

2024-02-13