Shared genetic effect of kidney function on bipolar and major depressive disorders: a large-scale genome-wide cross-trait analysis.
Yu S, Lin Y, Yang Y et al.
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Abstract
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Epidemiological studies have revealed a significant association between impaired kidney function and certain mental disorders, particularly bipolar disorder (BIP) and major depressive disorder (MDD). However, the evidence regarding shared genetics and causality is limited due to residual confounding and reverse causation.
51,710 European ancestry individuals with bipolar disorder measurements, 852,678 European ancestry individuals with BUN measurements
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