Active: Mood disorder Clear all

GWAS 2024-02-26

Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci.

Lori A, Pearce BD et al.

Front Psychiatry

Mood disorders such as major depressive and bipolar disorders, along with posttraumatic stress disor...

Hospitalization rate in serious mental illnesses

5157

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-13

Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder.

Mundy J, Hübel C et al.

Am J Med Genet B Neuropsychiatr Genet

The Mood Disorder Questionnaire (MDQ) is a common screening tool for bipolar disorder that assesses ...

Concurrent manic symptoms in manic depressive disorder and/or anxiety disorders (sum score)

11568

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-07

Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population.

Humphries EM, Ahn K et al.

Mol Psychiatry

Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts have identifi...

Mood disorder

1672

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-30

Genome-wide association study of suicidal behaviour severity in mood disorders.

Zai CC, Fabbri C et al.

World J Biol Psychiatry

Objective: Suicide is a major public health problem and it has a prominent genetic component. We per...

Suicide attempt severity in mood disorders

3506

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-01

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.

Coleman JRI, Gaspar HA et al.

Biol Psychiatry

Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the p...

Bipolar disorder or major depressive disorder

625026

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-31

Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP.

Wigmore EM, Hafferty JD et al.

Pharmacogenomics J

Antidepressants demonstrate modest response rates in the treatment of major depressive disorder (MDD...

Antidepressant treatment resistance (> 2 drugs prescribed)

4229

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-14

Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

Guo W, Machado-Vieira R et al.

Transl Psychiatry

Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects...

Response to ketamine in bipolar disorder or major depression (antidepressant effects)

157

Participants

N/A

Studies

Details PubMed

GWAS 2016-10-25

The PHF21B gene is associated with major depression and modulates the stress response.

Wong ML, Arcos-Burgos M et al.

Mol Psychiatry

Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying...

Major depressive disorder

399

Participants

N/A

Studies

Details PubMed

GWAS 2016-05-24

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

Power RA, Tansey KE et al.

Biol Psychiatry

Major depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable componen...

Major depressive disorder

Replicated

155907

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-25

A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

Liu X, Kelsoe JR et al.

J Affect Disord

Bipolar disorder is a heterogeneous mood disorder associated with several important clinical comorbi...

Eating disorder in bipolar disorder

2190

Participants

N/A

Studies

Details PubMed

GWAS 2014-06-25

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.

Mullins N, Perroud N et al.

Am J Med Genet B Neuropsychiatr Genet

Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independ...

Suicidal ideation in depression or bipolar disorder

747

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-29

Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.

Sulkava S, Ollila HM et al.

Hum Mol Genet

Job-related exhaustion is the core dimension of burnout, a work-related stress syndrome that has sev...

Job-related exhaustion

Replicated

15120

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci.

Lori A, Pearce BD et al.

Front Psychiatry

Hospitalization rate in serious mental illnesses

2024-02-26

Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder.

Mundy J, Hübel C et al.

Am J Med Genet B Neuropsychiatr Genet

Concurrent manic symptoms in manic depressive disorder and/or anxiety disorders (sum score)

2023-05-13

Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population.

Humphries EM, Ahn K et al.

Mol Psychiatry

Mood disorder

2023-03-07

Genome-wide association study of suicidal behaviour severity in mood disorders.

Zai CC, Fabbri C et al.

World J Biol Psychiatry

Suicide attempt severity in mood disorders

2021-03-30

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.

Coleman JRI, Gaspar HA et al.

Biol Psychiatry

Bipolar disorder or major depressive disorder

2019-11-01

Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP.

Wigmore EM, Hafferty JD et al.

Pharmacogenomics J

Antidepressant treatment resistance (> 2 drugs prescribed)

2019-01-31

Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

Guo W, Machado-Vieira R et al.

Transl Psychiatry

Response to ketamine in bipolar disorder or major depression (antidepressant effects)

2018-12-14

The PHF21B gene is associated with major depression and modulates the stress response.

Wong ML, Arcos-Burgos M et al.

Mol Psychiatry

Major depressive disorder

2016-10-25

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

Power RA, Tansey KE et al.

Biol Psychiatry

Major depressive disorder

2016-05-24

A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

Liu X, Kelsoe JR et al.

J Affect Disord

Eating disorder in bipolar disorder

2015-09-25

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.

Mullins N, Perroud N et al.

Am J Med Genet B Neuropsychiatr Genet

Suicidal ideation in depression or bipolar disorder

2014-06-25

Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.

Sulkava S, Ollila HM et al.

Hum Mol Genet

Job-related exhaustion

2013-04-29