A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.
Liu X, Kelsoe JR, Greenwood TA
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Bipolar disorder is a heterogeneous mood disorder associated with several important clinical comorbidities, such as eating disorders. This clinical heterogeneity complicates the identification of genetic variants contributing to bipolar susceptibility. Here we investigate comorbidity of eating disorders as a subphenotype of bipolar disorder to identify genetic variation that is common and unique to both disorders.
184 European ancestry cases, 2,006 European ancestry controls
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