Active: Multiple myeloma Clear all

GWAS 2024-08-05

Deciphering the genetics and mechanisms of predisposition to multiple myeloma.

Went M, Duran-Lozano L et al.

Nat Commun

Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a...

Multiple myeloma

377127

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-20

Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma.

Tantawy M, Yang G et al.

Front Cardiovasc Med

Proteasome inhibitor Carfilzomib (CFZ) is effective in treating patients with refractory or relapsed...

Cardiovascular adverse events in carfilzomib-treated multiple myeloma

228

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-19

Germline variants at SOHLH2 influence multiple myeloma risk.

Duran-Lozano L, Thorleifsson G et al.

Blood Cancer J

Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there i...

Multiple myeloma or monoclonal gammopathy of undetermined significance

Replicated

427613

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-01

Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance.

Clay-Gilmour AI, Hildebrandt MAT et al.

Blood Adv

So far, 23 germline susceptibility loci have been associated with multiple myeloma (MM) risk. It is ...

Multiple myeloma

5139

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-01

A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.

Du Z, Weinhold N et al.

Blood Adv

Persons of African ancestry (AA) have a twofold higher risk for multiple myeloma (MM) compared with ...

Multiple myeloma

10684

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-13

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.

Went M, Sud A et al.

Nat Commun

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multi...

Multiple myeloma

Replicated

257530

Participants

N/A

Studies

Details PubMed

GWAS 2018-06-11

Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study.

Chattopadhyay S, Thomsen H et al.

Mol Med

Recent identification of 10 germline variants predisposing to monoclonal gammopathy of undetermined ...

Monoclonal gammopathy of undetermined significance

1528

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-28

Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study.

Apewokin S, Lee JY et al.

Support Care Cancer

Clostridium difficile infection (CDI) is the most common hospital-acquired infection. Unfortunately,...

Clostridium difficile infection in multiple myeloma

646

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-04

Genomewide association study on monoclonal gammopathy of unknown significance (MGUS).

Thomsen H, Campo C et al.

Eur J Haematol

Objectives: To identify germ line variants contributing to the development of monoclonal gammopathy ...

Monoclonal gammopathy of undetermined significance

Replicated

2094

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-23

Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

Law PJ, Sud A et al.

Sci Rep

B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages...

B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)

14421

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-01

Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients.

Campo C, da Silva Filho MI et al.

Hematol Oncol

The proteasome-inhibitor bortezomib was introduced into the treatment of multiple myeloma more than ...

Bortezomib-induced peripheral neuropathy in multiple myeloma

646

Participants

N/A

Studies

Details PubMed

GWAS 2016-12-27

Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma.

da Silva Filho MI, Försti A et al.

Leukemia

Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers ...

Immunoglobulin light chain (AL) amyloidosis

8755

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Deciphering the genetics and mechanisms of predisposition to multiple myeloma.

Went M, Duran-Lozano L et al.

Nat Commun

Multiple myeloma

2024-08-05

Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma.

Tantawy M, Yang G et al.

Front Cardiovasc Med

Cardiovascular adverse events in carfilzomib-treated multiple myeloma

2023-06-20

Germline variants at SOHLH2 influence multiple myeloma risk.

Duran-Lozano L, Thorleifsson G et al.

Blood Cancer J

Multiple myeloma or monoclonal gammopathy of undetermined significance

2021-04-19

Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance.

Clay-Gilmour AI, Hildebrandt MAT et al.

Blood Adv

Multiple myeloma

2020-06-01

A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.

Du Z, Weinhold N et al.

Blood Adv

Multiple myeloma

2020-01-01

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.

Went M, Sud A et al.

Nat Commun

Multiple myeloma

2018-09-13

Enrichment of B cell receptor signaling and epidermal growth factor receptor pathways in monoclonal gammopathy of undetermined significance: a genome-wide genetic interaction study.

Chattopadhyay S, Thomsen H et al.

Mol Med

Monoclonal gammopathy of undetermined significance

2018-06-11

Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study.

Apewokin S, Lee JY et al.

Support Care Cancer

Clostridium difficile infection in multiple myeloma

2018-03-28

Genomewide association study on monoclonal gammopathy of unknown significance (MGUS).

Thomsen H, Campo C et al.

Eur J Haematol

Monoclonal gammopathy of undetermined significance

2017-04-04

Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

Law PJ, Sud A et al.

Sci Rep

B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)

2017-01-23

Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients.

Campo C, da Silva Filho MI et al.

Hematol Oncol

Bortezomib-induced peripheral neuropathy in multiple myeloma

2017-01-01

Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma.

da Silva Filho MI, Försti A et al.

Leukemia

Immunoglobulin light chain (AL) amyloidosis

2016-12-27