Active: Nicotine metabolite ratio in current smokers Clear all

GWAS 2021-10-01

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.

Chenoweth MJ, Cox LS et al.

Sci Rep

Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3'hydroxycotinine. ...

Nicotine metabolite ratio in current smokers

Replicated

945

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-10

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.

Buchwald J, Chenoweth MJ et al.

Mol Psychiatry

Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are alt...

Nicotine metabolite ratio in current smokers

5185

Participants

N/A

Studies

Details PubMed

GWAS 2017-09-16

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.

Chenoweth MJ, Ware JJ et al.

Addiction

Background and aims: The activity of CYP2A6, the major nicotine-inactivating enzyme, is measurable i...

Nicotine metabolite ratio in current smokers

Replicated

1434

Participants

N/A

Studies

Details PubMed

GWAS 2016-08-03

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.

Patel YM, Park SL et al.

Cancer Res

Metabolism of nicotine by cytochrome P450 2A6 (CYP2A6) is a suspected determinant of smoking dose an...

Nicotine metabolite ratio in current smokers

2239

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-25

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

Loukola A, Buchwald J et al.

PLoS Genet

Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smok...

Nicotine metabolite ratio in current smokers

1518

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

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Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.

Chenoweth MJ, Cox LS et al.

Sci Rep

Nicotine metabolite ratio in current smokers

2021-10-01

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.

Buchwald J, Chenoweth MJ et al.

Mol Psychiatry

Nicotine metabolite ratio in current smokers

2020-03-10

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.

Chenoweth MJ, Ware JJ et al.

Addiction

Nicotine metabolite ratio in current smokers

2017-09-16

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.

Patel YM, Park SL et al.

Cancer Res

Nicotine metabolite ratio in current smokers

2016-08-03

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

Loukola A, Buchwald J et al.

PLoS Genet

Nicotine metabolite ratio in current smokers

2015-09-25