Active: Opioid use disorder Clear all

GWAS 2024-03-01

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily o...

Pain intensity (without opioid use disorder)

416740

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-15

A genome-wide association, polygenic risk score and sex study on opioid use disorder treatment outcomes.

McEvoy A, Chawar C et al.

Sci Rep

Opioid use disorder continues to be a health concern with a high rate of opioid related deaths occur...

Continued opioids use after methadone maintenance treatment in opioid use disorder

2157

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-08

Identifying Genetic Loci and Phenomic Associations of Substance Use Traits: A Multi-trait Analysis of GWAS (MTAG) study.

Xu H, Toikumo S et al.

Addiction

Background and aims: Genome-wide association studies (GWAS) of opioid use disorder (OUD) and cannabi...

Opioid use disorder (MTAG)

74635

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-22

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

Hatoum AS, Colbert SMC et al.

Nat Ment Health

Genetic liability to substance use disorders can be parsed into loci that confer general or substanc...

Addiction risk factors

647703

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-28

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.

Kember RL, Vickers-Smith R et al.

Nat Neurosci

Despite an estimated heritability of ~50%, genome-wide association studies of opioid use disorder (O...

Opioid use disorder

447521

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-25

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.

Deak JD, Zhou H et al.

Mol Psychiatry

Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD t...

Opioid use disorder

554186

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-02

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

Sanchez-Roige S, Fontanillas P et al.

Mol Psychiatry

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis. Ample evide...

Problematic opioid prescription use

132113

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-28

Analysis of genetic and clinical factors associated with buprenorphine response.

Crist RC, Vickers-Smith R et al.

Drug Alcohol Depend

Buprenorphine, approved for treating opioid use disorder (OUD), is not equally efficacious for all p...

Response to buprenorphine in opioid use disorder

1609

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-26

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.

Karlsson Linnér R, Mallard TT et al.

Nat Neurosci

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior and a...

Externalizing behaviour (multivariate analysis)

1492085

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-15

Genome-wide association analysis of opioid use disorder: A novel approach using clinical data.

Song W, Kossowsky J et al.

Drug Alcohol Depend

Opioid use disorder (OUD) represents a large and pervasive global public health challenge. Previous ...

Opioid use disorder vs exposed controls

11783

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-03

Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.

Zhou H, Rentsch CT et al.

JAMA Psychiatry

Importance: With the current opioid crisis, it is important to improve understanding of the biologic...

Opioid use disorder

Replicated

476650

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-31

Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.

Alblooshi H, Al Safar H et al.

BMC Psychiatry

Genome Wide Association Studies (GWAS) have been conducted to identify genes and pathways involved i...

Opioid use disorder

452

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Pain intensity (without opioid use disorder)

2024-03-01

A genome-wide association, polygenic risk score and sex study on opioid use disorder treatment outcomes.

McEvoy A, Chawar C et al.

Sci Rep

Continued opioids use after methadone maintenance treatment in opioid use disorder

2023-12-15

Identifying Genetic Loci and Phenomic Associations of Substance Use Traits: A Multi-trait Analysis of GWAS (MTAG) study.

Xu H, Toikumo S et al.

Addiction

Opioid use disorder (MTAG)

2023-05-08

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

Hatoum AS, Colbert SMC et al.

Nat Ment Health

Addiction risk factors

2023-03-22

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.

Kember RL, Vickers-Smith R et al.

Nat Neurosci

Opioid use disorder

2022-09-28

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.

Deak JD, Zhou H et al.

Mol Psychiatry

Opioid use disorder

2022-07-25

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

Sanchez-Roige S, Fontanillas P et al.

Mol Psychiatry

Problematic opioid prescription use

2021-11-02

Analysis of genetic and clinical factors associated with buprenorphine response.

Crist RC, Vickers-Smith R et al.

Drug Alcohol Depend

Response to buprenorphine in opioid use disorder

2021-08-28

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.

Karlsson Linnér R, Mallard TT et al.

Nat Neurosci

Externalizing behaviour (multivariate analysis)

2021-08-26

Genome-wide association analysis of opioid use disorder: A novel approach using clinical data.

Song W, Kossowsky J et al.

Drug Alcohol Depend

Opioid use disorder vs exposed controls

2020-09-15

Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.

Zhou H, Rentsch CT et al.

JAMA Psychiatry

Opioid use disorder

2020-06-03

Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.

Alblooshi H, Al Safar H et al.

BMC Psychiatry

Opioid use disorder

2020-01-31