Active: Parkinson disease Clear all

GWAS 2023-09-29

A genome-wide association study coupled with machine learning approaches to identify influential demographic and genomic factors underlying Parkinson's disease.

Rahman MA, Liu J

Front Genet

Despite the recent success of genome-wide association studies (GWAS) in identifying 90 independent r...

Parkinson disease

7072

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-08

Genome-wide Analysis of Motor Progression in Parkinson Disease.

Martínez Carrasco A, Real R et al.

Neurol Genet

Background and objectives: The genetic basis of Parkinson disease (PD) motor progression is largely ...

Parkinson disease axial motor severity

3572

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-26

Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.

Grover S, Kumar Sreelatha AA et al.

Neurology

Background and objectives: Considerable heterogeneity exists in the literature concerning genetic de...

Age of onset of parkinson disease

8535

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-06

Common X-Chromosome Variants Are Associated with Parkinson Disease Risk.

Le Guen Y, Napolioni V et al.

Ann Neurol

Objective: The objective of this study was to identify genetic variants on the X-chromosome associat...

Parkinson's disease

Replicated

304760

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-28

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes.

Alfradique-Dunham I, Al-Ouran R et al.

Neurol Genet

Objective: To discover genetic determinants of Parkinson disease (PD) motor subtypes, including trem...

Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty)

2829

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-20

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.

Foo JN, Chew EGY et al.

JAMA Neurol

Importance: Large-scale genome-wide association studies in the European population have identified 9...

Parkinson's disease

Replicated

1961445

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-05

Plasticity-related gene 3 (LPPR1) and age at diagnosis of Parkinson disease.

Wallen ZD, Chen H et al.

Neurol Genet

Objective: To identify modifiers of age at diagnosis of Parkinson disease (PD).

Parkinson's disease (age at diagnosis)

Replicated

2676

Participants

N/A

Studies

Details PubMed

GWAS 2016-05-16

Detection and interpretation of shared genetic influences on 42 human traits.

Pickrell JK, Berisa T et al.

Nat Genet

We performed a scan for genetic variants associated with multiple phenotypes by comparing large geno...

Parkinson's disease

334141

Participants

N/A

Studies

Details PubMed

GWAS 2015-11-01

Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults.

Dong J, Yang J et al.

Medicine (Baltimore)

Olfactory dysfunction is common among older adults and affects their safety, nutrition, quality of l...

Sense of smell

6252

Participants

N/A

Studies

Details PubMed

GWAS 2015-08-02

The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson disease.

Gan-Or Z, Amshalom I et al.

J Neurol

GBA mutations are among the most common genetic risk factors for Parkinson disease (PD) worldwide. W...

Parkinson's disease in GBA mutation carriers (age at onset)

Replicated

154

Participants

N/A

Studies

Details PubMed

GWAS 2015-02-06

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Beecham GW, Dickson DW et al.

Neurology

Objective: To minimize pathologic heterogeneity in genetic studies of Parkinson disease (PD), the Au...

Parkinson disease and lewy body pathology

1629

Participants

N/A

Studies

Details PubMed

GWAS 2014-05-19

Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.

Vacic V, Ozelius LJ et al.

Hum Mol Genet

The recent series of large genome-wide association studies in European and Japanese cohorts establis...

Parkinson's disease

Replicated

6630

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A genome-wide association study coupled with machine learning approaches to identify influential demographic and genomic factors underlying Parkinson's disease.

Rahman MA, Liu J

Front Genet

Parkinson disease

2023-09-29

Genome-wide Analysis of Motor Progression in Parkinson Disease.

Martínez Carrasco A, Real R et al.

Neurol Genet

Parkinson disease axial motor severity

2023-08-08

Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.

Grover S, Kumar Sreelatha AA et al.

Neurology

Age of onset of parkinson disease

2022-05-26

Common X-Chromosome Variants Are Associated with Parkinson Disease Risk.

Le Guen Y, Napolioni V et al.

Ann Neurol

Parkinson's disease

2021-03-06

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes.

Alfradique-Dunham I, Al-Ouran R et al.

Neurol Genet

Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty)

2021-01-28

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study.

Foo JN, Chew EGY et al.

JAMA Neurol

Parkinson's disease

2020-04-20

Wallen ZD, Chen H et al.

Neurol Genet

Parkinson's disease (age at diagnosis)

2018-10-05

Detection and interpretation of shared genetic influences on 42 human traits.

Pickrell JK, Berisa T et al.

Nat Genet

Parkinson's disease

2016-05-16

Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults.

Dong J, Yang J et al.

Medicine (Baltimore)

Sense of smell

2015-11-01

The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson disease.

Gan-Or Z, Amshalom I et al.

J Neurol

Parkinson's disease in GBA mutation carriers (age at onset)

2015-08-02

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Beecham GW, Dickson DW et al.

Neurology

Parkinson disease and lewy body pathology

2015-02-06

Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.

Vacic V, Ozelius LJ et al.

Hum Mol Genet

Parkinson's disease

2014-05-19