Active: Periodontitis Clear all

GWAS 2023-12-23

A genome-wide association study meta-analysis in a European sample of stage III/IV grade C periodontitis patients ≤35 years of age identifies new risk loci.

De Almeida SD, Richter GM et al.

J Clin Periodontol

Aim: Few genome-wide association studies (GWAS) have been conducted for severe forms of periodontiti...

Aggressive periodontitis

9123

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-27

Candidate loci shared among periodontal disease, diabetes and bone density.

Yu YH, Steffensen B et al.

Front Endocrinol (Lausanne)

Introduction: While periodontal disease (PD) has been associated with type 2 diabetes (T2D) and oste...

Periodontitis / loose teeth (MTAG)

506594

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-18

Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans.

Freitag-Wolf S, Munz M et al.

J Clin Periodontol

Aims: Various studies have reported that young European women are more likely to develop early-onset...

Early onset periodontitis x sex interaction

896

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-21

Genome-wide association study of stage III/IV grade C periodontitis (former aggressive periodontitis) in a Spanish population.

de Coo A, Cruz R et al.

J Clin Periodontol

Aim: To identify loci associated with stages III/IV, grade C periodontitis (PIII/IV-C) through a gen...

Periodontitis (stage III/IV grade C)

1644

Participants

N/A

Studies

Details PubMed

GWAS 2019-09-19

Smoking Modifies the Genetic Risk for Early-Onset Periodontitis.

Freitag-Wolf S, Munz M et al.

J Dent Res

Periodontitis has low-prevalence, highly severe disease manifestations with an early onset and rapid...

Early onset periodontitis x smoking status interaction

741

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-24

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

Shungin D, Haworth S et al.

Nat Commun

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet ...

Number of decayed, missing and filled tooth surfaces or use of dentures

487823

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-04

A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population.

Bevilacqua L, Navarra CO et al.

J Periodontal Res

Background and objective: Periodontitis in one of the most prevalent dental diseases. Despite numero...

Chronic periodontitis

602

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-14

Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.

Munz M, Richter GM et al.

Eur J Hum Genet

Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide fo...

Periodontitis

Replicated

15003

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-11

GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.

Offenbacher S, Jiao Y et al.

Nat Commun

There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal diseas...

High IL-1beta levels in gingival crevicular fluid

4910

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-25

A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.

Munz M, Willenborg C et al.

Hum Mol Genet

Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide fo...

Aggressive periodontitis

Replicated

8474

Participants

N/A

Studies

Details PubMed

GWAS 2016-09-06

Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos.

Sanders AE, Sofer T et al.

J Dent Res

Chronic periodontitis (CP) has a genetic component, particularly its severe forms. Evidence from gen...

Chronic periodontitis (mean interproximal clinical attachment level)

Replicated

16245

Participants

N/A

Studies

Details PubMed

GWAS 2016-04-20

The Novel ASIC2 Locus is Associated with Severe Gingival Inflammation.

Zhang S, Divaris K et al.

JDR Clin Trans Res

An increasing body of evidence suggests a significant genetic regulation of inflammatory response me...

Severe gingival inflammation

4077

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A genome-wide association study meta-analysis in a European sample of stage III/IV grade C periodontitis patients ≤35 years of age identifies new risk loci.

De Almeida SD, Richter GM et al.

J Clin Periodontol

Aggressive periodontitis

2023-12-23

Candidate loci shared among periodontal disease, diabetes and bone density.

Yu YH, Steffensen B et al.

Front Endocrinol (Lausanne)

Periodontitis / loose teeth (MTAG)

2023-01-27

Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans.

Freitag-Wolf S, Munz M et al.

J Clin Periodontol

Early onset periodontitis x sex interaction

2021-08-18

Genome-wide association study of stage III/IV grade C periodontitis (former aggressive periodontitis) in a Spanish population.

de Coo A, Cruz R et al.

J Clin Periodontol

Periodontitis (stage III/IV grade C)

2021-03-21

Smoking Modifies the Genetic Risk for Early-Onset Periodontitis.

Freitag-Wolf S, Munz M et al.

J Dent Res

Early onset periodontitis x smoking status interaction

2019-09-19

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

Shungin D, Haworth S et al.

Nat Commun

Number of decayed, missing and filled tooth surfaces or use of dentures

2019-06-24

A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population.

Bevilacqua L, Navarra CO et al.

J Periodontal Res

Chronic periodontitis

2018-10-04

Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.

Munz M, Richter GM et al.

Eur J Hum Genet

Periodontitis

2018-09-14

GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.

Offenbacher S, Jiao Y et al.

Nat Commun

High IL-1beta levels in gingival crevicular fluid

2018-09-11

A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.

Munz M, Willenborg C et al.

Hum Mol Genet

Aggressive periodontitis

2017-04-25

Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos.

Sanders AE, Sofer T et al.

J Dent Res

Chronic periodontitis (mean interproximal clinical attachment level)

2016-09-06

The Novel ASIC2 Locus is Associated with Severe Gingival Inflammation.

Zhang S, Divaris K et al.

JDR Clin Trans Res

Severe gingival inflammation

2016-04-20