Active: Smoking cessation Clear all

GWAS 2025-01-10

Genome-wide association study of varenicline-aided smoking cessation.

Coley K, Wang Q et al.

Nicotine Tob Res

Introduction: Varenicline is an α4β2 nicotinic acetylcholine receptor partial agonist with the highe...

Response to varenicline (short-term effectiveness)

Replicated

4717

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-19

Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome-Wide Investigation of Abnormal Dreams on Varenicline.

Chenoweth MJ, Kim YJ et al.

Clin Pharmacol Ther

Varenicline, the most efficacious smoking cessation monotherapy, produces abnormal dreams. Although ...

Abnormal dreams on treatment with varenicline in smokers

Replicated

325

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-14

Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults.

Deng WQ, Belisario K et al.

Genes Brain Behav

Impulsivity refers to a number of conceptually related phenotypes reflecting self-regulatory capacit...

Impulsive action factor

1534

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-01

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.

Chenoweth MJ, Cox LS et al.

Sci Rep

Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3'hydroxycotinine. ...

Nicotine metabolite ratio in current smokers

Replicated

945

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-17

A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival.

Shen S, Wei Y et al.

NPJ Precis Oncol

The genetic architecture of non-small cell lung cancer (NSCLC) is relevant to smoking status. Howeve...

Lung cancer prognosis in former smokers

1299

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-13

A genome-wide association study of nausea incidence in varenicline-treated cigarette smokers.

Chenoweth MJ, Lerman C et al.

Nicotine Tob Res

Introduction: Varenicline is the most efficacious smoking cessation treatment; however, long-term ce...

Nausea incidence in varenicline-treated smokers

189

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-20

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.

Xu K, Li B et al.

Nat Commun

Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 2...

Smoking status (current vs mixed)

202116

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-10

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.

Buchwald J, Chenoweth MJ et al.

Mol Psychiatry

Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are alt...

Nicotine metabolite ratio in current smokers

5185

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-07

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Erzurumluoglu AM, Liu M et al.

Mol Psychiatry

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common ...

Smoking initiation

Replicated

622409

Participants

N/A

Studies

Details PubMed

GWAS 2016-09-19

The Genetic Landscape of Renal Complications in Type 1 Diabetes.

Sandholm N, Van Zuydam N et al.

J Am Soc Nephrol

Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of diabetic k...

Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes

Replicated

11665

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-25

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

Loukola A, Buchwald J et al.

PLoS Genet

Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smok...

Nicotine metabolite ratio in current smokers

1518

Participants

N/A

Studies

Details PubMed

GWAS 2014-03-22

A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.

Zhang R, Chu M et al.

Carcinogenesis

Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis. However, approx...

Lung cancer (smoking interaction)

Replicated

8431

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study of varenicline-aided smoking cessation.

Coley K, Wang Q et al.

Nicotine Tob Res

Response to varenicline (short-term effectiveness)

2025-01-10

Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome-Wide Investigation of Abnormal Dreams on Varenicline.

Chenoweth MJ, Kim YJ et al.

Clin Pharmacol Ther

Abnormal dreams on treatment with varenicline in smokers

2024-02-19

Deng WQ, Belisario K et al.

Genes Brain Behav

Impulsive action factor

2023-04-14

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.

Chenoweth MJ, Cox LS et al.

Sci Rep

Nicotine metabolite ratio in current smokers

2021-10-01

A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival.

Shen S, Wei Y et al.

NPJ Precis Oncol

Lung cancer prognosis in former smokers

2021-05-17

A genome-wide association study of nausea incidence in varenicline-treated cigarette smokers.

Chenoweth MJ, Lerman C et al.

Nicotine Tob Res

Nausea incidence in varenicline-treated smokers

2021-03-13

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.

Xu K, Li B et al.

Nat Commun

Smoking status (current vs mixed)

2020-10-20

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.

Buchwald J, Chenoweth MJ et al.

Mol Psychiatry

Nicotine metabolite ratio in current smokers

2020-03-10

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Erzurumluoglu AM, Liu M et al.

Mol Psychiatry

Smoking initiation

2019-01-07

The Genetic Landscape of Renal Complications in Type 1 Diabetes.

Sandholm N, Van Zuydam N et al.

J Am Soc Nephrol

Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes

2016-09-19

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

Loukola A, Buchwald J et al.

PLoS Genet

Nicotine metabolite ratio in current smokers

2015-09-25

A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.

Zhang R, Chu M et al.

Carcinogenesis

Lung cancer (smoking interaction)

2014-03-22