A genome-wide association study of nausea incidence in varenicline-treated cigarette smokers.
Chenoweth MJ, Lerman C, Knight J et al.
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Abstract
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Introduction: Varenicline is the most efficacious smoking cessation treatment; however, long-term cessation rates tend to be <25%. Nausea, the most common side effect of varenicline, observed in ~28% of individuals treated, peaks early following treatment initiation and reduces cessation success. Genetic variation influences treatment response, however genetic contributors to individual differences in side effects are less understood.
57 European ancestry cases, 132 European ancestry controls
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