Active: Systolic blood pressure Clear all

GWAS 2025-09-26

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Genetic predisposition to central adiposity is associated with metabolic dysfunction and obesity-rel...

Waist circumference

49188

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-04

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

Nagarajan P, Winkler TW et al.

Mol Psychiatry

Although both short and long sleep duration are associated with elevated hypertension risk, our unde...

Systolic blood pressure x short total sleep time interaction (main effect)

810633

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-25

Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.

Sadler MC, Apostolov A et al.

Nat Commun

Electronic health records (EHRs) coupled with large-scale biobanks offer great promises to unravel t...

Systolic blood pressure response to angiotensin-converting enzyme inhibitors (absolute difference)

Replicated

5034

Participants

N/A

Studies

Details PubMed

GWAS 2024-12-10

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

While brainstem regions are central regulators of blood pressure, the neuronal mechanisms underlying...

Systolic blood pressure

174014

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-21

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause of morbidi...

Dilated cardiomyopathy

Replicated

2404278

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-15

Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.

Teixeira SK, Rossi FPN et al.

Sci Rep

Despite the identification of numerous genetic variants affecting SBP in European populations, their...

Systolic blood pressure

286581

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-24

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.

Pozarickij A, Gan W et al.

Nat Commun

Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide ass...

Systolic blood pressure (BMI unadjusted)

100453

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-30

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

Keaton JM, Kamali Z et al.

Nat Genet

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, report...

Systolic blood pressure

Replicated

1091027

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-16

Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study.

Singh S, Choudhury A et al.

Nat Commun

Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, ...

Systolic blood pressure

10772

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-13

Quantifying the causal impact of biological risk factors on healthcare costs.

Lee J, Jukarainen S et al.

Nat Commun

Understanding the causal impact that clinical risk factors have on healthcare-related costs is criti...

Annual healthcare cost

373160

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-31

Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents.

Pike MM, Schildcrout J et al.

J Am Heart Assoc

Background Genetics, along with lifestyle and behavioral characteristics, play an important role in ...

Childhood median systolic blood pressure percentile

9778

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-08

The genetic architecture of blood pressure variability: A genome-wide association study of 9370 participants from UK Biobank.

Jia P, Zhan N et al.

J Clin Hypertens (Greenwich)

Long-term blood pressure variability (BPV) is a risk factor for cardiovascular diseases, dementia, a...

Systolic blood pressure variability

9370

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.

Gumilang RA, Bai CH

Int J Obes (Lond)

Waist circumference

2025-09-26

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.

Nagarajan P, Winkler TW et al.

Mol Psychiatry

Systolic blood pressure x short total sleep time interaction (main effect)

2025-04-04

Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.

Sadler MC, Apostolov A et al.

Nat Commun

Systolic blood pressure response to angiotensin-converting enzyme inhibitors (absolute difference)

2025-03-25

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

Systolic blood pressure

2024-12-10

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy

2024-11-21

Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.

Teixeira SK, Rossi FPN et al.

Sci Rep

Systolic blood pressure

2024-11-15

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.

Pozarickij A, Gan W et al.

Nat Commun

Systolic blood pressure (BMI unadjusted)

2024-07-24

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

Keaton JM, Kamali Z et al.

Nat Genet

Systolic blood pressure

2024-04-30

Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study.

Singh S, Choudhury A et al.

Nat Commun

Systolic blood pressure

2023-12-16

Quantifying the causal impact of biological risk factors on healthcare costs.

Lee J, Jukarainen S et al.

Nat Commun

Annual healthcare cost

2023-09-13

Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents.

Pike MM, Schildcrout J et al.

J Am Heart Assoc

Childhood median systolic blood pressure percentile

2023-01-31

The genetic architecture of blood pressure variability: A genome-wide association study of 9370 participants from UK Biobank.

Jia P, Zhan N et al.

J Clin Hypertens (Greenwich)

Systolic blood pressure variability

2022-08-08