Active: Visual acuity Clear all

GWAS 2024-06-01

Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations.

Gelernter J, Levey DF et al.

Cell Genom

Epiretinal membrane (ERM) is a common retinal condition characterized by the presence of fibrocellul...

Epiretinal membrane

445426

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-25

Identification of loci involved in childhood visual acuity and associations with cognitive skills and educational attainment.

Schmitz J, Abbondanza F et al.

NPJ Sci Learn

Visual acuity significantly contributes to quality of life. Deficits in childhood are associated wit...

Visual acuity

557

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-06

Identifying Genetic Biomarkers Predicting Response to Anti-Vascular Endothelial Growth Factor Injections in Diabetic Macular Edema.

Gurung RL, FitzGerald LM et al.

Int J Mol Sci

Intraocular anti-vascular endothelial growth factor (VEGF) therapies are the front-line treatment fo...

Response to anti-vascular endothelial growth factor drug in diabetic macular edema (central macular thickness)

220

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-12

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.

Currant H, Hysi P et al.

PLoS Genet

Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnos...

Retinal nerve fibre layer (RNFL) thickness

31434

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-01

Association of a Variant in VWA3A with Response to Anti-Vascular Endothelial Growth Factor Treatment in Neovascular AMD.

Grunin M, Beykin G et al.

Invest Ophthalmol Vis Sci

Purpose: Anti-vascular endothelial growth factor (VEGF) therapy for neovascular AMD (nvAMD) obtains ...

Response to anti-VEGF treatment in neovascular age-related macular degeneration (visual acuity)

Replicated

295

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-02

A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity.

Meng W, Chan BW et al.

Ophthalmic Genet

Diabetic maculopathy is a form of diabetic retinopathy. The visual acuity of one third of patients w...

Diabetic maculopathy with decreased visual acuity in type 2 diabetes

1843

Participants

N/A

Studies

Details PubMed

GWAS 2018-07-27

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration.

Akiyama M, Takahashi A et al.

J Hum Genet

To identify factors associated with ranibizumab responses in patients with exudative age-related mac...

Response to ranibizumab in age-related macular degeneration (exudative)

Replicated

919

Participants

N/A

Studies

Details PubMed

GWAS 2018-05-31

Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration.

Lorés-Motta L, Riaz M et al.

JAMA Ophthalmol

Importance: Visual acuity (VA) outcomes differ considerably among patients with neovascular age-rela...

Response to anti-VEGF treatment in neovascular age-related macular degeneration (visual acuity)

Replicated

2058

Participants

N/A

Studies

Details PubMed

GWAS 2017-08-23

A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration.

Yamashiro K, Mori K et al.

Sci Rep

We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudat...

Response to ranibizumab in age-related macular degeneration (visual acuity)

Replicated

461

Participants

N/A

Studies

Details PubMed

GWAS 2012-02-16

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Bakken TE, Roddey JC et al.

Proc Natl Acad Sci U S A

Visual cortical surface area varies two- to threefold between human individuals, is highly heritable...

Occipital cortical area (total cortical area interaction)

Replicated

1181

Participants

N/A

Studies

Details PubMed

GWAS 2011-12-01

Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.

Fan Q, Zhou X et al.

PLoS Genet

Corneal astigmatism refers to refractive abnormalities and irregularities in the curvature of the co...

Corneal astigmatism

Replicated

8513

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations.

Gelernter J, Levey DF et al.

Cell Genom

Epiretinal membrane

2024-06-01

Identification of loci involved in childhood visual acuity and associations with cognitive skills and educational attainment.

Schmitz J, Abbondanza F et al.

NPJ Sci Learn

Visual acuity

2023-07-25

Identifying Genetic Biomarkers Predicting Response to Anti-Vascular Endothelial Growth Factor Injections in Diabetic Macular Edema.

Gurung RL, FitzGerald LM et al.

Int J Mol Sci

Response to anti-vascular endothelial growth factor drug in diabetic macular edema (central macular thickness)

2022-04-06

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.

Currant H, Hysi P et al.

PLoS Genet

Retinal nerve fibre layer (RNFL) thickness

2021-05-12

Association of a Variant in VWA3A with Response to Anti-Vascular Endothelial Growth Factor Treatment in Neovascular AMD.

Grunin M, Beykin G et al.

Invest Ophthalmol Vis Sci

Response to anti-VEGF treatment in neovascular age-related macular degeneration (visual acuity)

2020-02-01

A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity.

Meng W, Chan BW et al.

Ophthalmic Genet

Diabetic maculopathy with decreased visual acuity in type 2 diabetes

2019-07-02

Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration.

Akiyama M, Takahashi A et al.

J Hum Genet

Response to ranibizumab in age-related macular degeneration (exudative)

2018-07-27

Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration.

Lorés-Motta L, Riaz M et al.

JAMA Ophthalmol

Response to anti-VEGF treatment in neovascular age-related macular degeneration (visual acuity)

2018-05-31

A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration.

Yamashiro K, Mori K et al.

Sci Rep

Response to ranibizumab in age-related macular degeneration (visual acuity)

2017-08-23

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Bakken TE, Roddey JC et al.

Proc Natl Acad Sci U S A

Occipital cortical area (total cortical area interaction)

2012-02-16

Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.

Fan Q, Zhou X et al.

PLoS Genet

Corneal astigmatism

2011-12-01