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GWAS 2019-12-13

General regression model: A "model-free" association test for quantitative traits allowing to test for the underlying genetic model.

Gloaguen E, Dizier MH et al.

Ann Hum Genet

Most genome-wide association studies used genetic-model-based tests assuming an additive mode of inh...

Hemoglobin A1c levels

695

Participants

N/A

Studies

Details PubMed

GWAS 2015-05-22

Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA).

Larson NB, Berardi C et al.

Ann Hum Genet

Hepatocyte growth factor (HGF) is a mesenchyme-derived pleiotropic factor that regulates cell growth...

Hepatocyte growth factor levels

6201

Participants

N/A

Studies

Details PubMed

GWAS 2013-08-13

A genome-wide search for type 2 diabetes susceptibility genes in an extended Arab family.

Al Safar HS, Cordell HJ et al.

Ann Hum Genet

Twenty percent of people aged 20 to 79 have type 2 diabetes (T2D) in the United Arab Emirates (UAE)....

Type 2 diabetes

Replicated

493

Participants

N/A

Studies

Details PubMed

GWAS 2013-05-01

Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.

Naj AC, Scott WK et al.

Ann Hum Genet

Relatively little is known about the interaction between genes and environment in the complex etiolo...

Age-related macular degeneration

Replicated

2101

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-02

Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.

Zhao L, Bracken MB et al.

Ann Hum Genet

A genome-wide association study was undertaken to identify maternal single nucleotide polymorphisms ...

Preeclampsia

3003

Participants

N/A

Studies

Details PubMed

GWAS 2013-03-28

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.

Jeff JM, Ritchie MD et al.

Ann Hum Genet

Electrocardiographic (ECG) measurements vary by ancestry. Genome-wide association studies (GWAS) hav...

QT interval

455

Participants

N/A

Studies

Details PubMed

GWAS 2012-09-01

Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.

Cummings AC, Jiang L et al.

Ann Hum Genet

To identify novel late-onset Alzheimer disease (LOAD) risk genes, we have analysed Amish populations...

Alzheimer's disease (late onset)

798

Participants

N/A

Studies

Details PubMed

GWAS 2012-01-09

Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.

Karns R, Zhang G et al.

Ann Hum Genet

A genome-wide association study of serum uric acid (SUA) laevels was performed in a relatively isola...

Uric acid levels

1300

Participants

N/A

Studies

Details PubMed

GWAS 2011-11-28

A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family.

Datta S, Chowdhury A et al.

Ann Hum Genet

Variants in the UGT1A1 gene and its promoter are known to determine levels of unconjugated bilirubin...

Bilirubin levels

182

Participants

N/A

Studies

Details PubMed

GWAS 2011-07-21

Evidence for age as a modifier of genetic associations for lipid levels.

Dumitrescu L, Brown-Gentry K et al.

Ann Hum Genet

In order to identify novel genetic variants that influence plasma lipid concentrations, we performed...

Lipid traits

Replicated

4959

Participants

N/A

Studies

Details PubMed

GWAS 2010-09-16

The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis.

Franklin CS, Aulchenko YS et al.

Ann Hum Genet

Genome-wide association (GWA) studies have identified around 20 common genetic variants influencing ...

Glycated hemoglobin levels

1782

Participants

N/A

Studies

Details PubMed

GWAS 2010-01-13

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

Edwards TL, Scott WK et al.

Ann Hum Genet

Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of great...

Parkinson's disease

3497

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

General regression model: A "model-free" association test for quantitative traits allowing to test for the underlying genetic model.

Gloaguen E, Dizier MH et al.

Ann Hum Genet

Hemoglobin A1c levels

2019-12-13

Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA).

Larson NB, Berardi C et al.

Ann Hum Genet

Hepatocyte growth factor levels

2015-05-22

A genome-wide search for type 2 diabetes susceptibility genes in an extended Arab family.

Al Safar HS, Cordell HJ et al.

Ann Hum Genet

Type 2 diabetes

2013-08-13

Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.

Naj AC, Scott WK et al.

Ann Hum Genet

Age-related macular degeneration

2013-05-01

Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.

Zhao L, Bracken MB et al.

Ann Hum Genet

Preeclampsia

2013-04-02

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.

Jeff JM, Ritchie MD et al.

Ann Hum Genet

QT interval

2013-03-28

Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.

Cummings AC, Jiang L et al.

Ann Hum Genet

Alzheimer's disease (late onset)

2012-09-01

Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.

Karns R, Zhang G et al.

Ann Hum Genet

Uric acid levels

2012-01-09

A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family.

Datta S, Chowdhury A et al.

Ann Hum Genet

Bilirubin levels

2011-11-28

Evidence for age as a modifier of genetic associations for lipid levels.

Dumitrescu L, Brown-Gentry K et al.

Ann Hum Genet

Lipid traits

2011-07-21

The TCF7L2 diabetes risk variant is associated with HbA₁(C) levels: a genome-wide association meta-analysis.

Franklin CS, Aulchenko YS et al.

Ann Hum Genet

Glycated hemoglobin levels

2010-09-16

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

Edwards TL, Scott WK et al.

Ann Hum Genet

Parkinson's disease

2010-01-13