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GWAS 2025-06-26

A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population.

Hu J, Jiang G et al.

Diabetologia

Aims/hypothesis: We aimed to generate a population-specific type 1 diabetes genetic risk score (GRS)...

Type 1 diabetes

Replicated

137980

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-01

Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.

Chebii VJ, Wade AN et al.

Diabetologia

Aims/hypothesis: Glycaemic traits such as high fasting glucose levels and insulin resistance are pos...

Fasting glucose adjusted for BMI

9989

Participants

N/A

Studies

Details PubMed

GWAS 2024-12-02

Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.

Chen Y, Torta F et al.

Diabetologia

Aims/hypothesis: This study aims to explore the association between plasma metabolites and chronic k...

Cholesterol ester (CE.22.5) levels in type 2 diabetes

6350

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-19

Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits.

Zhen J, Gu Y et al.

Diabetologia

Aims/hypothesis: Gestational diabetes mellitus (GDM) is the most common disorder in pregnancy; howev...

Gestational diabetes mellitus

Replicated

28265

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-17

Metabolomic and genetic architecture of gestational diabetes subtypes.

Lee K, Kuang A et al.

Diabetologia

Aims/hypothesis: Physiological gestational diabetes mellitus (GDM) subtypes that may confer differen...

Gestational diabetes mellitus

8067

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-07

Genetic associations vary across the spectrum of fasting serum insulin: results from the European IDEFICS/I.Family children's cohort.

Mehlig K, Foraita R et al.

Diabetologia

Aims/hypothesis: There is increasing evidence for the existence of shared genetic predictors of meta...

Fasting insulin z-score (<15th percentile)

2825

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-06

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.

Hawkes G, Beaumont RN et al.

Diabetologia

Aims/hypothesis: Determining how high BMI at different time points influences the risk of developing...

Childhood body mass index

441761

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-26

Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.

Li JH, Brenner LN et al.

Diabetologia

Aims/hypothesis: Characterisation of genetic variation that influences the response to glucose-lower...

Response to metformin (Insulin area under the curve)

730

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-06

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.

Huerta-Chagoya A, Schroeder P et al.

Diabetologia

Aims/hypothesis: The Latino population has been systematically underrepresented in large-scale genet...

Type 2 diabetes (adjusted for BMI)

Replicated

53324

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-13

Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.

Rudman N, Kaur S et al.

Diabetologia

Aims/hypothesis: We previously demonstrated that N-glycosylation of plasma proteins and IgGs is diff...

Plasma protein N-glycan peak 29 levels in type 1 diabetes

Replicated

1529

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-30

A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome.

Liu Q, Tang B et al.

Diabetologia

Aims/hypothesis: The link underlying abnormal glucose metabolism, type 2 diabetes and polycystic ova...

Type 2 diabetes or polycystic ovary syndrome (pleiotropy)

1011368

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-28

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.

Sandholm N, Cole JB et al.

Diabetologia

Aims/hypothesis: Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a subs...

Kidney disese (macroalbuminuria or end-stage renal disease) in diabetes

22134

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population.

Hu J, Jiang G et al.

Diabetologia

Type 1 diabetes

2025-06-26

Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.

Chebii VJ, Wade AN et al.

Diabetologia

Fasting glucose adjusted for BMI

2025-03-01

Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.

Chen Y, Torta F et al.

Diabetologia

Cholesterol ester (CE.22.5) levels in type 2 diabetes

2024-12-02

Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits.

Zhen J, Gu Y et al.

Diabetologia

Gestational diabetes mellitus

2024-02-19

Metabolomic and genetic architecture of gestational diabetes subtypes.

Lee K, Kuang A et al.

Diabetologia

Gestational diabetes mellitus

2024-02-17

Genetic associations vary across the spectrum of fasting serum insulin: results from the European IDEFICS/I.Family children's cohort.

Mehlig K, Foraita R et al.

Diabetologia

Fasting insulin z-score (<15th percentile)

2023-07-07

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.

Hawkes G, Beaumont RN et al.

Diabetologia

Childhood body mass index

2023-06-06

Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.

Li JH, Brenner LN et al.

Diabetologia

Response to metformin (Insulin area under the curve)

2023-05-26

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.

Huerta-Chagoya A, Schroeder P et al.

Diabetologia

Type 2 diabetes (adjusted for BMI)

2023-05-06

Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.

Rudman N, Kaur S et al.

Diabetologia

Plasma protein N-glycan peak 29 levels in type 1 diabetes

2023-03-13

A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome.

Liu Q, Tang B et al.

Diabetologia

Type 2 diabetes or polycystic ovary syndrome (pleiotropy)

2022-06-30

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.

Sandholm N, Cole JB et al.

Diabetologia

Kidney disese (macroalbuminuria or end-stage renal disease) in diabetes

2022-06-28