Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.
Hawkes G, Beaumont RN, Tyrrell J et al.
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Abstract
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Aims/hypothesis: Determining how high BMI at different time points influences the risk of developing type 2 diabetes and affects insulin secretion and insulin sensitivity is critical.
441,761 European ancestry individuals
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