Active: Gastroenterology Clear all

GWAS 2024-02-27

Comprehensive association analyses of extraintestinal manifestations in inflammatory bowel disease.

Khrom M, Long M et al.

Gastroenterology

Background & aims: Patients with inflammatory bowel disease (IBD) frequently develop extraintest...

Extraintestinal manifestations in inflammatory bowel disease (ankylosing spondylitis and sacroiliitis)

12027

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-13

Genome wide association study identifies 4 novel risk loci for small intestinal neuroendocrine tumors including a missense mutation in LGR5.

Giri AK, Aavikko M et al.

Gastroenterology

Background & aims: Small intestinal neuroendocrine tumor (SI-NET) is a rare disease, but its inc...

Small intestine neuroendocrine tumor

Replicated

615071

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-31

Proteome-wide Mendelian randomization identifies causal links between blood proteins and acute pancreatitis.

Bourgault J, Abner E et al.

Gastroenterology

Background & aims: Acute pancreatitis (AP) is a complex disease and the leading cause of gastroi...

Acute pancreatitis

855309

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-12

Integrative analysis of the Inflammatory Bowel Disease serum metabolome improves our understanding of genetic etiology and points to novel putative therapeutic targets.

Di'Narzo AF, Houten SM et al.

Gastroenterology

Background & aims: Polygenic and environmental factors are underlying causes of inflammatory bow...

5alpha-androstan-3alpha,17beta-diol monosulfate (2) levels

712

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-24

Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort.

Gettler K, Levantovsky R et al.

Gastroenterology

Background and aims: Polygenic risk scores (PRS) may soon be used to predict inflammatory bowel dise...

Inflammatory bowel disease

48257

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-10

Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study.

Emdin CA, Haas M et al.

Gastroenterology

Background & aims: In contrast to most other common diseases, few genetic variants have been ide...

Cirrhosis (multi-trait analysis)

Replicated

786913

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-09

Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.

Dong J, Maj C et al.

Gastroenterology

Background & aims: Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophag...

Barrett's esophagus or esophageal adenocarcinoma x sex interaction (1df test)

22091

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-16

Genome-wide Association Study for Alcohol-related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1.

Innes H, Buch S et al.

Gastroenterology

Background and aims: Little is known about genetic factors that affect development of alcohol-relate...

Forns index in high alcohol intake

33437

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-05

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Sazonovs A, Kennedy NA et al.

Gastroenterology

Background & aims: Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biol...

Immunogenicity to anti-TNF therapy in Crohn's disease

Replicated

1347

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-18

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Cirulli ET, Nicoletti P et al.

Gastroenterology

Background & aims: We performed genetic analyses of a multiethnic cohort of patients with idiosy...

Drug-induced liver injury

Replicated

253894

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-26

Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.

Vergara C, Thio CL et al.

Gastroenterology

Background & aims: Spontaneous clearance of hepatitis C virus (HCV) occurs in approximately 30% ...

Hepatitis C (spontaneous viral clearance)

4423

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-06

Large-scale Genome-wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

Lu Y, Kweon SS et al.

Gastroenterology

Background & aims: Genome-wide association studies (GWASs) have associated approximately 50 loci...

Colorectal cancer

70506

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Comprehensive association analyses of extraintestinal manifestations in inflammatory bowel disease.

Khrom M, Long M et al.

Gastroenterology

Extraintestinal manifestations in inflammatory bowel disease (ankylosing spondylitis and sacroiliitis)

2024-02-27

Genome wide association study identifies 4 novel risk loci for small intestinal neuroendocrine tumors including a missense mutation in LGR5.

Giri AK, Aavikko M et al.

Gastroenterology

Small intestine neuroendocrine tumor

2023-07-13

Proteome-wide Mendelian randomization identifies causal links between blood proteins and acute pancreatitis.

Bourgault J, Abner E et al.

Gastroenterology

Acute pancreatitis

2023-01-31

Integrative analysis of the Inflammatory Bowel Disease serum metabolome improves our understanding of genetic etiology and points to novel putative therapeutic targets.

Di'Narzo AF, Houten SM et al.

Gastroenterology

5alpha-androstan-3alpha,17beta-diol monosulfate (2) levels

2021-11-12

Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort.

Gettler K, Levantovsky R et al.

Gastroenterology

Inflammatory bowel disease

2020-12-24

Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study.

Emdin CA, Haas M et al.

Gastroenterology

Cirrhosis (multi-trait analysis)

2020-12-10

Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.

Dong J, Maj C et al.

Gastroenterology

Barrett's esophagus or esophageal adenocarcinoma x sex interaction (1df test)

2020-09-09

Genome-wide Association Study for Alcohol-related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1.

Innes H, Buch S et al.

Gastroenterology

Forns index in high alcohol intake

2020-06-16

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Sazonovs A, Kennedy NA et al.

Gastroenterology

Immunogenicity to anti-TNF therapy in Crohn's disease

2019-10-05

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Cirulli ET, Nicoletti P et al.

Gastroenterology

Drug-induced liver injury

2019-01-18

Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.

Vergara C, Thio CL et al.

Gastroenterology

Hepatitis C (spontaneous viral clearance)

2018-12-26

Large-scale Genome-wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

Lu Y, Kweon SS et al.

Gastroenterology

Colorectal cancer

2018-12-06