Active: Genet Epidemiol Clear all

GWAS 2025-04-01

Sex-Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome-Wide Association Study of All of Us and UK Biobank Data.

Hu Y, Che M et al.

Genet Epidemiol

Major depressive disorder (MDD) is prevalent worldwide, substantially and negatively impacting both ...

Major depressive disorder

Replicated

569098

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-01

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.

Crouch DJM, Inshaw JRJ et al.

Genet Epidemiol

Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or bi...

Type 1 diabetes

173981

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-18

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Alade A, Peter T et al.

Genet Epidemiol

Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%-80%) of all OFCs. They can ...

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

3178

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-24

Deep learning identified genetic variants for COVID-19-related mortality among 28,097 affected cases in UK Biobank.

Liu Z, Dai W et al.

Genet Epidemiol

Analysis of host genetic components provides insights into the susceptibility and response to viral ...

Mortality in COVID-19

18731

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-21

Secondary analyses for genome-wide association studies using expression quantitative trait loci.

Ngwa JS, Yanek LR et al.

Genet Epidemiol

Genome-wide association studies (GWAS) have successfully identified thousands of single nucleotide p...

Platelet aggregation

806

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-22

Genome-wide association study of multiethnic nonsyndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypes.

Mukhopadhyay N, Feingold E et al.

Genet Epidemiol

Nonsyndromic orofacial clefts (OFCs) are among the most common craniofacial birth defects worldwide,...

Cleft lip or cleft lip with cleft palate

4891

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-18

Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms.

Qi G, Dutta D et al.

Genet Epidemiol

Physical inactivity (PA) is an important risk factor for a wide range of diseases. Previous genome-w...

Mid-point of the ten most active hours of the day

88411

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-06

Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.

Zhu X, Zhu L et al.

Genet Epidemiol

Systolic and diastolic blood pressure (S/DBP) are highly correlated modifiable risk factors for card...

Blood pressure (pleiotropy model 1 DBP adjusted for estimated causal effects x SBP)

1076492

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-29

Genome-wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals.

Gao C, Marcketta A et al.

Genet Epidemiol

Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers for liver h...

Alanine aminotransferase levels

388865

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-15

FAT4 identified as a potential modifier of orofacial cleft laterality.

Curtis SW, Chang D et al.

Genet Epidemiol

Orofacial clefts (OFCs) are common (1 in 700 births) congenital malformations that include a cleft l...

Unilateral cleft lip (left vs right)

Replicated

672

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-29

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Goddard PC, Keys KL et al.

Genet Epidemiol

Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung f...

Lung function (FVC) in asthma

104

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-22

Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.

Palmer MR, Kim DS et al.

Genet Epidemiol

Carotid artery atherosclerotic disease (CAAD) is a risk factor for stroke. We used a genome-wide ass...

Carotid artery stenosis

Replicated

408961

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Sex-Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome-Wide Association Study of All of Us and UK Biobank Data.

Hu Y, Che M et al.

Genet Epidemiol

Major depressive disorder

2025-04-01

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.

Crouch DJM, Inshaw JRJ et al.

Genet Epidemiol

Type 1 diabetes

2025-01-01

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Alade A, Peter T et al.

Genet Epidemiol

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

2024-04-18

Deep learning identified genetic variants for COVID-19-related mortality among 28,097 affected cases in UK Biobank.

Liu Z, Dai W et al.

Genet Epidemiol

Mortality in COVID-19

2023-01-24

Secondary analyses for genome-wide association studies using expression quantitative trait loci.

Ngwa JS, Yanek LR et al.

Genet Epidemiol

Platelet aggregation

2022-03-21

Genome-wide association study of multiethnic nonsyndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypes.

Mukhopadhyay N, Feingold E et al.

Genet Epidemiol

Cleft lip or cleft lip with cleft palate

2022-02-22

Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms.

Qi G, Dutta D et al.

Genet Epidemiol

Mid-point of the ten most active hours of the day

2022-01-18

Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.

Zhu X, Zhu L et al.

Genet Epidemiol

Blood pressure (pleiotropy model 1 DBP adjusted for estimated causal effects x SBP)

2022-01-06

Genome-wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals.

Gao C, Marcketta A et al.

Genet Epidemiol

Alanine aminotransferase levels

2021-06-29

FAT4 identified as a potential modifier of orofacial cleft laterality.

Curtis SW, Chang D et al.

Genet Epidemiol

Unilateral cleft lip (left vs right)

2021-06-15

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Goddard PC, Keys KL et al.

Genet Epidemiol

Lung function (FVC) in asthma

2020-09-29

Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.

Palmer MR, Kim DS et al.

Genet Epidemiol

Carotid artery stenosis

2020-09-22