Active: JAMA Clear all

GWAS 2019-11-01

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Hauser MA, Allingham RR et al.

JAMA

Importance: Primary open-angle glaucoma presents with increased prevalence and a higher degree of cl...

Glaucoma (primary open-angle)

Replicated

26132

Participants

N/A

Studies

Details PubMed

GWAS 2019-02-01

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

Walker GJ, Harrison JW et al.

JAMA

Importance: Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing iden...

Thiopurine-induced myelosuppression in inflammatory bowel disease

919

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-01

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.

Choi SH, Weng LC et al.

JAMA

Importance: Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population. Y...

Early onset atrial fibrillation

7740

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-01

Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.

Lotta LA, Wittemans LBL et al.

JAMA

Importance: Body fat distribution, usually measured using waist-to-hip ratio (WHR), is an important ...

Waist-to-hip ratio adjusted for BMI

660648

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-01

Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.

De T, Alarcon C et al.

JAMA

Importance: Major warfarin-related bleeding occurs more frequently in African Americans than in othe...

Warfarin-associated bleeding

Replicated

403

Participants

N/A

Studies

Details PubMed

GWAS 2015-03-17

Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.

Nan H, Hutter CM et al.

JAMA

Importance: Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated wit...

Colorectal cancer (aspirin and/or NSAID use interaction)

17187

Participants

N/A

Studies

Details PubMed

GWAS 2015-02-24

Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.

Diouf B, Crews KR et al.

JAMA

Importance: With cure rates of childhood acute lymphoblastic leukemia (ALL) exceeding 85%, there is ...

Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia

321

Participants

N/A

Studies

Details PubMed

GWAS 2014-08-06

Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.

Chung WH, Chang WC et al.

JAMA

Importance: The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from mac...

Phenytoin-induced severe cutaneous adverse reactions

Replicated

3890

Participants

N/A

Studies

Details PubMed

GWAS 2013-08-28

Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.

Qi L, Qi Q et al.

JAMA

Importance: Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous s...

Cardiovascular heart disease in diabetics

Replicated

4188

Participants

N/A

Studies

Details PubMed

GWAS 2013-08-21

Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.

Feenstra B, Geller F et al.

JAMA

Importance: Infantile hypertrophic pyloric stenosis (IHPS) is a serious condition in which hypertrop...

Infantile hypertrophic pyloric stenosis

Replicated

7353

Participants

N/A

Studies

Details PubMed

GWAS 2013-05-08

Identification of genetic loci associated with Helicobacter pylori serologic status.

Mayerle J, den Hoed CM et al.

JAMA

Importance: Helicobacter pylori is a major cause of gastritis and gastroduodenal ulcer disease and c...

Helicobacter pylori serologic status

10485

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-10

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.

Reitz C, Jun G et al.

JAMA

Importance: Genetic variants associated with susceptibility to late-onset Alzheimer disease are know...

Alzheimer's disease (late onset)

5896

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Hauser MA, Allingham RR et al.

JAMA

Glaucoma (primary open-angle)

2019-11-01

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

Walker GJ, Harrison JW et al.

JAMA

Thiopurine-induced myelosuppression in inflammatory bowel disease

2019-02-01

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.

Choi SH, Weng LC et al.

JAMA

Early onset atrial fibrillation

2018-12-01

Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.

Lotta LA, Wittemans LBL et al.

JAMA

Waist-to-hip ratio adjusted for BMI

2018-12-01

Association of Genetic Variants With Warfarin-Associated Bleeding Among Patients of African Descent.

De T, Alarcon C et al.

JAMA

Warfarin-associated bleeding

2018-10-01

Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.

Nan H, Hutter CM et al.

JAMA

Colorectal cancer (aspirin and/or NSAID use interaction)

2015-03-17

Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.

Diouf B, Crews KR et al.

JAMA

Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia

2015-02-24

Genetic variants associated with phenytoin-related severe cutaneous adverse reactions.

Chung WH, Chang WC et al.

JAMA

Phenytoin-induced severe cutaneous adverse reactions

2014-08-06

Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.

Qi L, Qi Q et al.

JAMA

Cardiovascular heart disease in diabetics

2013-08-28

Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.

Feenstra B, Geller F et al.

JAMA

Infantile hypertrophic pyloric stenosis

2013-08-21

Identification of genetic loci associated with Helicobacter pylori serologic status.

Mayerle J, den Hoed CM et al.

JAMA

Helicobacter pylori serologic status

2013-05-08

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.

Reitz C, Jun G et al.

JAMA

Alzheimer's disease (late onset)

2013-04-10