Active: Nat Neurosci Clear all

GWAS 2025-11-11

A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.

Smeland OB, Kutrolli G et al.

Nat Neurosci

Although neurological and psychiatric disorders have historically been considered to reflect distinc...

Total cortical surface area

32877

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-28

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.

Kember RL, Vickers-Smith R et al.

Nat Neurosci

Despite an estimated heritability of ~50%, genome-wide association studies of opioid use disorder (O...

Opioid use disorder

447521

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-05

Genetic variants associated with longitudinal changes in brain structure across the lifespan.

Brouwer RM, Klein M et al.

Nat Neurosci

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are ...

Amygdala volume change rate

15100

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-26

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.

Karlsson Linnér R, Mallard TT et al.

Nat Neurosci

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior and a...

Externalizing behaviour (multivariate analysis)

1492085

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-08

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders.

Yang C, Farias FHG et al.

Nat Neurosci

Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechani...

PCSK9 level (CSF)

835

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-27

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.

Levey DF, Stein MB et al.

Nat Neurosci

Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of veterans. H...

Major depressive disorder

Replicated

250215

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-19

An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.

Smith SM, Douaud G et al.

Nat Neurosci

UK Biobank is a major prospective epidemiological study, including multimodal brain imaging, genetic...

IDP T2 FLAIR BIANCA WMH volume

Replicated

32114

Participants

N/A

Studies

Details PubMed

GWAS 2020-05-25

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.

Zhou H, Sealock JM et al.

Nat Neurosci

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-...

Alcohol use disorder

313959

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-29

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.

Gelernter J, Sun N et al.

Nat Neurosci

Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike...

Post-traumatic stress disorder (re-experiencing symptoms)

Replicated

284543

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-17

Genome-wide association study implicates CHRNA2 in cannabis use disorder.

Demontis D, Rajagopal VM et al.

Nat Neurosci

Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten use...

Mental disorder

Replicated

51372

Participants

N/A

Studies

Details PubMed

GWAS 2019-02-04

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

Howard DM, Adams MJ et al.

Nat Neurosci

Major depression is a debilitating psychiatric illness that is typically associated with low mood an...

Depression

Replicated

2113907

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-28

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment.

Schork AJ, Won H et al.

Nat Neurosci

There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but ...

Mental disorder

Replicated

72697

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.

Smeland OB, Kutrolli G et al.

Nat Neurosci

Total cortical surface area

2025-11-11

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.

Kember RL, Vickers-Smith R et al.

Nat Neurosci

Opioid use disorder

2022-09-28

Genetic variants associated with longitudinal changes in brain structure across the lifespan.

Brouwer RM, Klein M et al.

Nat Neurosci

Amygdala volume change rate

2022-04-05

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.

Karlsson Linnér R, Mallard TT et al.

Nat Neurosci

Externalizing behaviour (multivariate analysis)

2021-08-26

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders.

Yang C, Farias FHG et al.

Nat Neurosci

PCSK9 level (CSF)

2021-07-08

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.

Levey DF, Stein MB et al.

Nat Neurosci

Major depressive disorder

2021-05-27

An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.

Smith SM, Douaud G et al.

Nat Neurosci

IDP T2 FLAIR BIANCA WMH volume

2021-04-19

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.

Zhou H, Sealock JM et al.

Nat Neurosci

Alcohol use disorder

2020-05-25

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.

Gelernter J, Sun N et al.

Nat Neurosci

Post-traumatic stress disorder (re-experiencing symptoms)

2019-07-29

Genome-wide association study implicates CHRNA2 in cannabis use disorder.

Demontis D, Rajagopal VM et al.

Nat Neurosci

Mental disorder

2019-06-17

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

Howard DM, Adams MJ et al.

Nat Neurosci

Depression

2019-02-04

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment.

Schork AJ, Won H et al.

Nat Neurosci

Mental disorder

2019-01-28