Active: PLoS Genet Clear all

GWAS 2025-12-01

Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.

Sadler MC, Ghobril JP et al.

PLoS Genet

Zinc is essential for many physiological processes and its deficiency is highly prevalent worldwide....

Urinary zinc levels

10103

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-11

Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers.

Francis M, Westerman KE et al.

PLoS Genet

We examined the associations of vegetarianism with metabolic biomarkers using traditional and geneti...

Sex hormone binding globulin levels (adjusted for BMI) x vegetarianism interaction

133007

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-03

A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma.

Wu X, Xiao C et al.

PLoS Genet

Age at first sexual intercourse (AFS) and lifetime number of sexual partners (NSP) may influence the...

Age at first sexual intercourse or uterine leiomyoma (pleiotropy)

517526

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-22

Canadian COVID-19 host genetics cohort replicates known severity associations.

Garg E, Arguello-Pascualli P et al.

PLoS Genet

The HostSeq initiative recruited 10,059 Canadians infected with SARS-CoV-2 between March 2020 and Ma...

Severe COVID-19 infection

8474

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-14

Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D.

Wang X, Hivert V et al.

PLoS Genet

Vitamin D status-a complex trait influenced by environmental and genetic factors-is tightly associat...

25-Hydroxyvitamin D levels

8306

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-23

Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.

Pasanen A, Karjalainen MK et al.

PLoS Genet

Preterm birth (<37 weeks of gestation) is a major cause of neonatal death and morbidity. Up to 40...

Gestational duration

Replicated

24391

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-16

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.

Mocci E, Ward K et al.

PLoS Genet

Chronic pain is at epidemic proportions in the United States, represents a significant burden on our...

Pain (pleiotropy)

361194

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-30

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.

Baltramonaityte V, Pingault JB et al.

PLoS Genet

Coronary artery disease (CAD), type 2 diabetes (T2D) and depression are among the leading causes of ...

Psycho-cardiometabolic multimorbidity (multivariate analysis)

562507

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-23

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.

Van Buren E, Radicioni G et al.

PLoS Genet

Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lu...

MUC5B concentration x pack-years of smoking interaction (2df)

215

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-27

Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation.

Currant H, Fitzgerald TW et al.

PLoS Genet

Photoreceptor cells (PRCs) are the light-detecting cells of the retina. Such cells can be non-invasi...

Outer nuclear layer (ONL) thickness

31135

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-09

GWAS on retinal vasculometry phenotypes.

Jiang X, Hysi PG et al.

PLoS Genet

The eye is the window through which light is transmitted and visual sensory signalling originates. I...

Retinal arteriolar tortuosity

Replicated

57785

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-19

Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort.

Hui D, Mehrabi S et al.

PLoS Genet

Loss or absence of hearing is common at both extremes of human lifespan, in the forms of congenital ...

Hearing loss

36507

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.

Sadler MC, Ghobril JP et al.

PLoS Genet

Urinary zinc levels

2025-12-01

Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers.

Francis M, Westerman KE et al.

PLoS Genet

Sex hormone binding globulin levels (adjusted for BMI) x vegetarianism interaction

2024-07-11

A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma.

Wu X, Xiao C et al.

PLoS Genet

Age at first sexual intercourse or uterine leiomyoma (pleiotropy)

2024-05-03

Canadian COVID-19 host genetics cohort replicates known severity associations.

Garg E, Arguello-Pascualli P et al.

PLoS Genet

Severe COVID-19 infection

2024-03-22

Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D.

Wang X, Hivert V et al.

PLoS Genet

25-Hydroxyvitamin D levels

2023-11-14

Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.

Pasanen A, Karjalainen MK et al.

PLoS Genet

Gestational duration

2023-10-23

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.

Mocci E, Ward K et al.

PLoS Genet

Pain (pleiotropy)

2023-10-16

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.

Baltramonaityte V, Pingault JB et al.

PLoS Genet

Psycho-cardiometabolic multimorbidity (multivariate analysis)

2023-06-30

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.

Van Buren E, Radicioni G et al.

PLoS Genet

MUC5B concentration x pack-years of smoking interaction (2df)

2023-06-23

Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation.

Currant H, Fitzgerald TW et al.

PLoS Genet

Outer nuclear layer (ONL) thickness

2023-02-27

GWAS on retinal vasculometry phenotypes.

Jiang X, Hysi PG et al.

PLoS Genet

Retinal arteriolar tortuosity

2023-02-09

Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort.

Hui D, Mehrabi S et al.

PLoS Genet

Hearing loss

2023-01-19