Active: PLoS Med Clear all

GWAS 2023-01-30

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study.

Hamilton FW, Thomas M et al.

PLoS Med

Sepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be ...

Appendicitis

486484

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-19

Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study.

Hodgson S, Huang QQ et al.

PLoS Med

Type 2 diabetes (T2D) is highly prevalent in British South Asians, yet they are underrepresented in ...

Type 2 diabetes

12875

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-30

Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium.

Hässler S, Bachelet D et al.

PLoS Med

Biopharmaceutical products (BPs) are widely used to treat autoimmune diseases, but immunogenicity li...

Anti-drug antibodies in autoimmune disease (time to event)

457

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-23

Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.

Dapas M, Lin FTJ et al.

PLoS Med

Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder affecting up to 15% of reprod...

Polycystic ovary syndrome (reproductive subtype)

Replicated

4305

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-23

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.

Richardson TG, Sanderson E et al.

PLoS Med

Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which...

LDL cholesterol levels

440546

Participants

N/A

Studies

Details PubMed

GWAS 2018-01-09

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

Broce I, Karch CM et al.

PLoS Med

Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathoge...

Frontotemporal dementia and immune-mediated diseases (pleiotropy)

149010

Participants

N/A

Studies

Details PubMed

GWAS 2017-09-12

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Wheeler E, Leong A et al.

PLoS Med

Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in...

Glycated hemoglobin levels

Replicated

158869

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-25

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

White CC, Yang HS et al.

PLoS Med

Introduction: The molecular underpinnings of the dissociation of cognitive performance and neuropath...

Residual cognition

979

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-29

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA, Scott RA et al.

PLoS Med

Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and v...

Branched-chain amino acid levels (Isoleucine)

19596

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study.

Hamilton FW, Thomas M et al.

PLoS Med

Appendicitis

2023-01-30

Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study.

Hodgson S, Huang QQ et al.

PLoS Med

Type 2 diabetes

2022-05-19

Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium.

Hässler S, Bachelet D et al.

PLoS Med

Anti-drug antibodies in autoimmune disease (time to event)

2020-10-30

Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.

Dapas M, Lin FTJ et al.

PLoS Med

Polycystic ovary syndrome (reproductive subtype)

2020-06-23

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.

Richardson TG, Sanderson E et al.

PLoS Med

LDL cholesterol levels

2020-03-23

Broce I, Karch CM et al.

PLoS Med

Frontotemporal dementia and immune-mediated diseases (pleiotropy)

2018-01-09

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Wheeler E, Leong A et al.

PLoS Med

Glycated hemoglobin levels

2017-09-12

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

White CC, Yang HS et al.

PLoS Med

Residual cognition

2017-04-25

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA, Scott RA et al.

PLoS Med

Branched-chain amino acid levels (Isoleucine)

2016-11-29