A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis.
Suzuki S, Yoshimura M, Nakayama M et al.
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Abstract
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Objective: Coronary spasm plays an important role in the pathogenesis of variant angina and also ischemic heart diseases in general, and it is more likely to occur in angiographically normal coronary arteries than in stenotic coronary arteries. We previously found a -786T/C polymorphism in the 5'-flanking region of the endothelial nitric oxide synthase (eNOS) gene and reported that this polymorphism is associated with coronary spasm. We report on an investigation of the genetic factor(s) associated with coronary spasm utilizing a genome-wide case-control study.
50 Japanese ancestry female cases, 50 Japanese ancestry female controls
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